Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts
We used intra-class effect decomposition (ICED) to evaluate the reliability of myelin water fraction (MWF) and geometric mean T2 relaxation time (geomT2IEW) estimated from a multi-echo MRI sequence. Our evaluation addressed test-retest reliability, with and without participant re-positioning, for se...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Neuroimage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956022000204 |
| _version_ | 1811257557377875968 |
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| author | Chaitali Anand Andreas M. Brandmaier Jonathan Lynn Muzamil Arshad Jeffrey A. Stanley Naftali Raz |
| author_facet | Chaitali Anand Andreas M. Brandmaier Jonathan Lynn Muzamil Arshad Jeffrey A. Stanley Naftali Raz |
| author_sort | Chaitali Anand |
| collection | DOAJ |
| description | We used intra-class effect decomposition (ICED) to evaluate the reliability of myelin water fraction (MWF) and geometric mean T2 relaxation time (geomT2IEW) estimated from a multi-echo MRI sequence. Our evaluation addressed test-retest reliability, with and without participant re-positioning, for seven commonly assessed white matter tracts: anterior and posterior limbs of the internal capsule, dorsal and ventral branches of the cingulum, the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, and the fornix in 20 healthy adults. We acquired two back-to-back scans in a single session, and a third after a break and repositioning the participant in the scanner. For both indices and for all white matter tracts assessed, reliability for an immediate retest, and after the participant's repositioning in the scanner was high. Variance partitioning revealed that in addition to measurement noise, which was significant in all regions, repositioning contributed to unreliability mainly in longer association fibers. Hemispheric location did not significantly contribute to unreliability in any region of interest (ROI). Thus, despite non-negligible error of measurement, for all ROIs, MWF and geomT2IEW have good test–retest reliability, regardless of the hemispheric location and are, therefore, suitable for longitudinal investigations in healthy adults. |
| first_indexed | 2024-04-12T17:59:19Z |
| format | Article |
| id | doaj.art-7a13c1916b4842f2a91b7b0005f41fd3 |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-04-12T17:59:19Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-7a13c1916b4842f2a91b7b0005f41fd32022-12-22T03:22:13ZengElsevierNeuroimage: Reports2666-95602022-06-0122100096Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tractsChaitali Anand0Andreas M. Brandmaier1Jonathan Lynn2Muzamil Arshad3Jeffrey A. Stanley4Naftali Raz5Department of Radiology, University of California, San Francisco, CA, USACenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Department of Psychology, MSB Medical School Berlin, Berlin, GermanyInstitute of Gerontology, Wayne State University, MI, USADepartment of Cellular and Radiation Oncology, University of Chicago Hospital, Chicago, IL, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USACenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Institute of Gerontology, Wayne State University, MI, USA; Department of Psychology, Wayne State University, Detroit, MI, USA; Corresponding author. Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.We used intra-class effect decomposition (ICED) to evaluate the reliability of myelin water fraction (MWF) and geometric mean T2 relaxation time (geomT2IEW) estimated from a multi-echo MRI sequence. Our evaluation addressed test-retest reliability, with and without participant re-positioning, for seven commonly assessed white matter tracts: anterior and posterior limbs of the internal capsule, dorsal and ventral branches of the cingulum, the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, and the fornix in 20 healthy adults. We acquired two back-to-back scans in a single session, and a third after a break and repositioning the participant in the scanner. For both indices and for all white matter tracts assessed, reliability for an immediate retest, and after the participant's repositioning in the scanner was high. Variance partitioning revealed that in addition to measurement noise, which was significant in all regions, repositioning contributed to unreliability mainly in longer association fibers. Hemispheric location did not significantly contribute to unreliability in any region of interest (ROI). Thus, despite non-negligible error of measurement, for all ROIs, MWF and geomT2IEW have good test–retest reliability, regardless of the hemispheric location and are, therefore, suitable for longitudinal investigations in healthy adults.http://www.sciencedirect.com/science/article/pii/S2666956022000204MyelinT2 relaxation timeMRIReliabilityMulti-echo imaging |
| spellingShingle | Chaitali Anand Andreas M. Brandmaier Jonathan Lynn Muzamil Arshad Jeffrey A. Stanley Naftali Raz Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts Neuroimage: Reports Myelin T2 relaxation time MRI Reliability Multi-echo imaging |
| title | Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts |
| title_full | Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts |
| title_fullStr | Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts |
| title_full_unstemmed | Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts |
| title_short | Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts |
| title_sort | test retest and repositioning effects of white matter microstructure measurements in selected white matter tracts |
| topic | Myelin T2 relaxation time MRI Reliability Multi-echo imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2666956022000204 |
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