Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy
Introduction Current hemostatic agents are needed to reduce bleeding and transfusion during several surgery processes. Plant-based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) are proposed for use in surgical wound sites as an absorbable hemostat and in this study,...
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| Format: | Article |
| Language: | English |
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Urology Research Center
2020-08-01
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| Series: | Translational Research in Urology |
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| Online Access: | https://www.transresurology.com/article_119549.html |
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| author | Seyed Mohammad Kazem Aghamir Mahdi Ramezani-binabaj Fatemeh Khatami Behrooz Fatahi |
| author_facet | Seyed Mohammad Kazem Aghamir Mahdi Ramezani-binabaj Fatemeh Khatami Behrooz Fatahi |
| author_sort | Seyed Mohammad Kazem Aghamir |
| collection | DOAJ |
| description | Introduction
Current hemostatic agents are needed to reduce bleeding and transfusion during several surgery processes. Plant-based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) are proposed for use in surgical wound sites as an absorbable hemostat and in this study, we checked its efficacy.
Methods
This study was run under the Tehran University of Medical Science Ethics Committee observation based on the clinical trial registry criteria (IRCT20190624043991N1). Total numbers of 42 percutaneous nephrolithotomies (PCNL) patients were enrolled, 21 cases hemostatic powder and 21 controls. Hemostatic powder pumped into Amplatz sheath before its extraction.
Results
The mean age of the case and control groups was 42.1±19.5, and 42.1±18.5 years, respectively. The median stone size was 11.3±1.85cm. Overall, the differences between sex, age, stone size, and location were not statistically significant in the two groups (p-value˃0.05). Serum hemoglobin reduction following PCNL was significant in both groups compared to the serum level before surgery (p-value<0.001). However, the difference was not significant between case and control groups postoperatively (p-value=0.727). Yet, postoperative serum creatinine reduction was not significantly different between the two groups compared to preoperative serum levels (p-value>0.05).
Conclusions
The present study showed that microporous polysaccharide hemosphere (MPH) did not affect bleeding reduction, hemoglobin decline, and postoperative blood transfusion, and hospital stay. |
| first_indexed | 2024-12-21T02:01:31Z |
| format | Article |
| id | doaj.art-7a15653f45d045fd8192bb1f99397dda |
| institution | Directory Open Access Journal |
| issn | 2717-042X |
| language | English |
| last_indexed | 2024-12-21T02:01:31Z |
| publishDate | 2020-08-01 |
| publisher | Urology Research Center |
| record_format | Article |
| series | Translational Research in Urology |
| spelling | doaj.art-7a15653f45d045fd8192bb1f99397dda2022-12-21T19:19:38ZengUrology Research CenterTranslational Research in Urology2717-042X2020-08-0123838810.22034/TRU.2020.257231.1047Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous NephrolithotomySeyed Mohammad Kazem Aghamir 0https://orcid.org/0000-0003-1611-0362Mahdi Ramezani-binabaj 1Fatemeh Khatami 2Behrooz Fatahi3Urology Research Center, Tehran University of Medical Sciences, Tehran, IranUrology Research Center, Tehran University of Medical Sciences, Tehran, IranUrology Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Urology, Lorestan University of Medical Sciences, Lorestan, IranIntroduction Current hemostatic agents are needed to reduce bleeding and transfusion during several surgery processes. Plant-based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) are proposed for use in surgical wound sites as an absorbable hemostat and in this study, we checked its efficacy. Methods This study was run under the Tehran University of Medical Science Ethics Committee observation based on the clinical trial registry criteria (IRCT20190624043991N1). Total numbers of 42 percutaneous nephrolithotomies (PCNL) patients were enrolled, 21 cases hemostatic powder and 21 controls. Hemostatic powder pumped into Amplatz sheath before its extraction. Results The mean age of the case and control groups was 42.1±19.5, and 42.1±18.5 years, respectively. The median stone size was 11.3±1.85cm. Overall, the differences between sex, age, stone size, and location were not statistically significant in the two groups (p-value˃0.05). Serum hemoglobin reduction following PCNL was significant in both groups compared to the serum level before surgery (p-value<0.001). However, the difference was not significant between case and control groups postoperatively (p-value=0.727). Yet, postoperative serum creatinine reduction was not significantly different between the two groups compared to preoperative serum levels (p-value>0.05). Conclusions The present study showed that microporous polysaccharide hemosphere (MPH) did not affect bleeding reduction, hemoglobin decline, and postoperative blood transfusion, and hospital stay.https://www.transresurology.com/article_119549.htmlhemostatic agentspercutaneous nephrolitotomytubeless surgeriesmicroporous polysaccharide hemospheres |
| spellingShingle | Seyed Mohammad Kazem Aghamir Mahdi Ramezani-binabaj Fatemeh Khatami Behrooz Fatahi Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy Translational Research in Urology hemostatic agents percutaneous nephrolitotomy tubeless surgeries microporous polysaccharide hemospheres |
| title | Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy |
| title_full | Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy |
| title_fullStr | Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy |
| title_full_unstemmed | Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy |
| title_short | Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy |
| title_sort | homeostatic efficacy of microporous polysaccharide hemosphere in post operative complications reduction of tubeless percutaneous nephrolithotomy |
| topic | hemostatic agents percutaneous nephrolitotomy tubeless surgeries microporous polysaccharide hemospheres |
| url | https://www.transresurology.com/article_119549.html |
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