A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells

A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells

We report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(...

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Bibliographic Details
Main Authors: Na Hee Kim, Junho Lee, Sungnam Park, Junyang Jung, Dokyoung Kim
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Sensors
Subjects:
fluorescent probe
Schiff base probe
iron ion sensing
D-A type fluorophore
bioimaging
Online Access:https://www.mdpi.com/1424-8220/19/11/2500
Description
Summary:We report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(III) in a HeLa cancer cell line, with very low cytotoxicity. As a new bio-imaging probe for Fe(III), it gave bright fluorescent images in confocal laser scanning microscopy (CLSM).
ISSN:1424-8220

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