A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells
We report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/19/11/2500 |
| _version_ | 1811277935013789696 |
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| author | Na Hee Kim Junho Lee Sungnam Park Junyang Jung Dokyoung Kim |
| author_facet | Na Hee Kim Junho Lee Sungnam Park Junyang Jung Dokyoung Kim |
| author_sort | Na Hee Kim |
| collection | DOAJ |
| description | We report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(III) in a HeLa cancer cell line, with very low cytotoxicity. As a new bio-imaging probe for Fe(III), it gave bright fluorescent images in confocal laser scanning microscopy (CLSM). |
| first_indexed | 2024-04-13T00:25:44Z |
| format | Article |
| id | doaj.art-7a17128d8bce4519b4ac8e599ac93879 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T00:25:44Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-7a17128d8bce4519b4ac8e599ac938792022-12-22T03:10:37ZengMDPI AGSensors1424-82202019-05-011911250010.3390/s19112500s19112500A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer CellsNa Hee Kim0Junho Lee1Sungnam Park2Junyang Jung3Dokyoung Kim4Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, KoreaDepartment of Chemistry, Korea University, Seoul 02841, KoreaDepartment of Chemistry, Korea University, Seoul 02841, KoreaDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, KoreaDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, KoreaWe report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(III) in a HeLa cancer cell line, with very low cytotoxicity. As a new bio-imaging probe for Fe(III), it gave bright fluorescent images in confocal laser scanning microscopy (CLSM).https://www.mdpi.com/1424-8220/19/11/2500fluorescent probeSchiff base probeiron ion sensingD-A type fluorophorebioimaging |
| spellingShingle | Na Hee Kim Junho Lee Sungnam Park Junyang Jung Dokyoung Kim A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells Sensors fluorescent probe Schiff base probe iron ion sensing D-A type fluorophore bioimaging |
| title | A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells |
| title_full | A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells |
| title_fullStr | A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells |
| title_full_unstemmed | A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells |
| title_short | A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells |
| title_sort | schiff base fluorescence enhancement probe for fe iii and its sensing applications in cancer cells |
| topic | fluorescent probe Schiff base probe iron ion sensing D-A type fluorophore bioimaging |
| url | https://www.mdpi.com/1424-8220/19/11/2500 |
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