Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management
Background: Multiple Myeloma is a B-cell malignancy which can cause variety of lesions of the spine and spinal cord. The management of patients with spinal cord compression (SCC), and the efficacy and security of minimally invasive therapeutic approaches, are the main topics of discussion. Methods:...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Journal of Craniovertebral Junction and Spine |
| Subjects: | |
| Online Access: | http://www.jcvjs.com/article.asp?issn=0974-8237;year=2023;volume=14;issue=4;spage=313;epage=318;aulast=Encarnacion |
| _version_ | 1797232754657591296 |
|---|---|
| author | Daniel Encarnacion Gennady E Chmutin Ismail Bozkurt Jack Wellington Emmanuel Batista Geraldino Bipin Chaurasia |
| author_facet | Daniel Encarnacion Gennady E Chmutin Ismail Bozkurt Jack Wellington Emmanuel Batista Geraldino Bipin Chaurasia |
| author_sort | Daniel Encarnacion |
| collection | DOAJ |
| description | Background: Multiple Myeloma is a B-cell malignancy which can cause variety of lesions of the spine and spinal cord. The management of patients with spinal cord compression (SCC), and the efficacy and security of minimally invasive therapeutic approaches, are the main topics of discussion.
Methods: To systematically review the scientific literature on neurosurgical aspects of MM spinal cord lesion management, a search was conducted among scientific papers in the databases ScienceDirect, Cochrane Library, and PubMed using keywords and Boolean operators. These comprise MM and lesions of the spine and spinal cord. Each database was searched from the earliest available article to January 2017.
Results: According to the literature, low-dose radiotherapy, antimyeloma medications, and bisphosphonates comprise the mainstay management for symptomatic spinal lesions. The decision to operation is based on presence of myelopathy and degree of spinal cord compression.
Conclusions: As a result of the analysis, the following conclusions may be drawn: (1) surgery is a valuable option for MM patients with symptomatic spinal involvement who experience rapid neurological deterioration with SCC and/or mechanical instability and (2) it is important to ensure that the benefits of surgical treatment outweigh the risks, as patients with MM are susceptible to infections. |
| first_indexed | 2024-04-24T16:05:18Z |
| format | Article |
| id | doaj.art-7a1818a1e8664f3aa38c6c578c762aa0 |
| institution | Directory Open Access Journal |
| issn | 0974-8237 |
| language | English |
| last_indexed | 2024-04-24T16:05:18Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Craniovertebral Junction and Spine |
| spelling | doaj.art-7a1818a1e8664f3aa38c6c578c762aa02024-04-01T05:54:48ZengWolters Kluwer Medknow PublicationsJournal of Craniovertebral Junction and Spine0974-82372023-01-0114431331810.4103/jcvjs.jcvjs_111_23Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient managementDaniel EncarnacionGennady E ChmutinIsmail BozkurtJack WellingtonEmmanuel Batista GeraldinoBipin ChaurasiaBackground: Multiple Myeloma is a B-cell malignancy which can cause variety of lesions of the spine and spinal cord. The management of patients with spinal cord compression (SCC), and the efficacy and security of minimally invasive therapeutic approaches, are the main topics of discussion. Methods: To systematically review the scientific literature on neurosurgical aspects of MM spinal cord lesion management, a search was conducted among scientific papers in the databases ScienceDirect, Cochrane Library, and PubMed using keywords and Boolean operators. These comprise MM and lesions of the spine and spinal cord. Each database was searched from the earliest available article to January 2017. Results: According to the literature, low-dose radiotherapy, antimyeloma medications, and bisphosphonates comprise the mainstay management for symptomatic spinal lesions. The decision to operation is based on presence of myelopathy and degree of spinal cord compression. Conclusions: As a result of the analysis, the following conclusions may be drawn: (1) surgery is a valuable option for MM patients with symptomatic spinal involvement who experience rapid neurological deterioration with SCC and/or mechanical instability and (2) it is important to ensure that the benefits of surgical treatment outweigh the risks, as patients with MM are susceptible to infections.http://www.jcvjs.com/article.asp?issn=0974-8237;year=2023;volume=14;issue=4;spage=313;epage=318;aulast=Encarnacionlesions of the spine and spinal cordmeta-analysismultiple myelomareview |
| spellingShingle | Daniel Encarnacion Gennady E Chmutin Ismail Bozkurt Jack Wellington Emmanuel Batista Geraldino Bipin Chaurasia Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management Journal of Craniovertebral Junction and Spine lesions of the spine and spinal cord meta-analysis multiple myeloma review |
| title | Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management |
| title_full | Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management |
| title_fullStr | Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management |
| title_full_unstemmed | Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management |
| title_short | Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management |
| title_sort | lesions of the spinal cord caused by multiple myeloma a systematic review and meta analysis regarding the neurosurgical aspects of patient management |
| topic | lesions of the spine and spinal cord meta-analysis multiple myeloma review |
| url | http://www.jcvjs.com/article.asp?issn=0974-8237;year=2023;volume=14;issue=4;spage=313;epage=318;aulast=Encarnacion |
| work_keys_str_mv | AT danielencarnacion lesionsofthespinalcordcausedbymultiplemyelomaasystematicreviewandmetaanalysisregardingtheneurosurgicalaspectsofpatientmanagement AT gennadyechmutin lesionsofthespinalcordcausedbymultiplemyelomaasystematicreviewandmetaanalysisregardingtheneurosurgicalaspectsofpatientmanagement AT ismailbozkurt lesionsofthespinalcordcausedbymultiplemyelomaasystematicreviewandmetaanalysisregardingtheneurosurgicalaspectsofpatientmanagement AT jackwellington lesionsofthespinalcordcausedbymultiplemyelomaasystematicreviewandmetaanalysisregardingtheneurosurgicalaspectsofpatientmanagement AT emmanuelbatistageraldino lesionsofthespinalcordcausedbymultiplemyelomaasystematicreviewandmetaanalysisregardingtheneurosurgicalaspectsofpatientmanagement AT bipinchaurasia lesionsofthespinalcordcausedbymultiplemyelomaasystematicreviewandmetaanalysisregardingtheneurosurgicalaspectsofpatientmanagement |