IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation
Among cyclic di-nucleotides (CDN), both cyclic di-AMP (CDA) and di-GMP (CDG) are promising adjuvants and immune modulators. These molecules are not only able to induce profuse antibody production but also predominant T helper 1 and cytotoxic CD8 T lymphocytes (CTL) responses, which enable their use...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/12/2821 |
| _version_ | 1797455724463259648 |
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| author | Ahmed E. I. Hamouda Kai Schulze Thomas Ebensen Carlos Alberto Guzmán Darío Lirussi |
| author_facet | Ahmed E. I. Hamouda Kai Schulze Thomas Ebensen Carlos Alberto Guzmán Darío Lirussi |
| author_sort | Ahmed E. I. Hamouda |
| collection | DOAJ |
| description | Among cyclic di-nucleotides (CDN), both cyclic di-AMP (CDA) and di-GMP (CDG) are promising adjuvants and immune modulators. These molecules are not only able to induce profuse antibody production but also predominant T helper 1 and cytotoxic CD8 T lymphocytes (CTL) responses, which enable their use for vaccination against intracellular pathogens as well as in cancer immunotherapy. However, for their successful translation into the clinic, a comprehensive understanding of CDN mode of action is still essential. Consistent with evidence in the literature, we show here that IFN-α/β (Type I IFN) is crucial for CDG-mediated B cell activation. We recently determined the key role of type I IFN signaling for CDA-mediated enhancement of immunogenicity. Based on the biological activities of type I IFN, in this study, we hypothesized that it might also be required for CTL induction by CDG. We disclose here the mode of action of type I IFN signaling in CDG-mediated cross-presentation and subsequent CTL generation. |
| first_indexed | 2024-03-09T15:57:29Z |
| format | Article |
| id | doaj.art-7a1978ee9c4a43ff89c3505c2d696595 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:57:29Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7a1978ee9c4a43ff89c3505c2d6965952023-11-24T17:22:36ZengMDPI AGPharmaceutics1999-49232022-12-011412282110.3390/pharmaceutics14122821IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte ActivationAhmed E. I. Hamouda0Kai Schulze1Thomas Ebensen2Carlos Alberto Guzmán3Darío Lirussi4Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyAmong cyclic di-nucleotides (CDN), both cyclic di-AMP (CDA) and di-GMP (CDG) are promising adjuvants and immune modulators. These molecules are not only able to induce profuse antibody production but also predominant T helper 1 and cytotoxic CD8 T lymphocytes (CTL) responses, which enable their use for vaccination against intracellular pathogens as well as in cancer immunotherapy. However, for their successful translation into the clinic, a comprehensive understanding of CDN mode of action is still essential. Consistent with evidence in the literature, we show here that IFN-α/β (Type I IFN) is crucial for CDG-mediated B cell activation. We recently determined the key role of type I IFN signaling for CDA-mediated enhancement of immunogenicity. Based on the biological activities of type I IFN, in this study, we hypothesized that it might also be required for CTL induction by CDG. We disclose here the mode of action of type I IFN signaling in CDG-mediated cross-presentation and subsequent CTL generation.https://www.mdpi.com/1999-4923/14/12/2821adjuvantimmunomodulatoryvaccinesIFN-α/βcyclic di-nucleotides |
| spellingShingle | Ahmed E. I. Hamouda Kai Schulze Thomas Ebensen Carlos Alberto Guzmán Darío Lirussi IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation Pharmaceutics adjuvant immunomodulatory vaccines IFN-α/β cyclic di-nucleotides |
| title | IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation |
| title_full | IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation |
| title_fullStr | IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation |
| title_full_unstemmed | IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation |
| title_short | IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation |
| title_sort | ifn α β signaling is required for cdg mediated ctl generation and b lymphocyte activation |
| topic | adjuvant immunomodulatory vaccines IFN-α/β cyclic di-nucleotides |
| url | https://www.mdpi.com/1999-4923/14/12/2821 |
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