Functional MRI responses to naturalistic stimuli are increasingly typical across early childhood
While findings show that throughout development, there are child- and age-specific patterns of brain functioning, there is also evidence for significantly greater inter-individual response variability in young children relative to adults. It is currently unclear whether this increase in functional “...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
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| Series: | Developmental Cognitive Neuroscience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000737 |
| _version_ | 1797777495278223360 |
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| author | Ryann Tansey Kirk Graff Christiane S. Rohr Dennis Dimond Amanda Ip Shelly Yin Deborah Dewey Signe Bray |
| author_facet | Ryann Tansey Kirk Graff Christiane S. Rohr Dennis Dimond Amanda Ip Shelly Yin Deborah Dewey Signe Bray |
| author_sort | Ryann Tansey |
| collection | DOAJ |
| description | While findings show that throughout development, there are child- and age-specific patterns of brain functioning, there is also evidence for significantly greater inter-individual response variability in young children relative to adults. It is currently unclear whether this increase in functional “typicality” (i.e., inter-individual similarity) is a developmental process that occurs across early childhood, and what changes in BOLD response may be driving changes in typicality. We collected fMRI data from 81 typically developing 4–8-year-old children during passive viewing of age-appropriate television clips and asked whether there is increasing typicality of brain response across this age range. We found that the “increasing typicality” hypothesis was supported across many regions engaged by passive viewing. Post hoc analyses showed that in a priori ROIs related to language and face processing, the strength of the group-average shared component of activity increased with age, with no concomitant decline in residual signal or change in spatial extent or variability. Together, this suggests that increasing inter-individual similarity of functional responses to audiovisual stimuli is an important feature of early childhood functional brain development. |
| first_indexed | 2024-03-12T23:04:44Z |
| format | Article |
| id | doaj.art-7a1979fafd434812807f0ec631f9621c |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-12T23:04:44Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-7a1979fafd434812807f0ec631f9621c2023-07-19T04:23:22ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-08-0162101268Functional MRI responses to naturalistic stimuli are increasingly typical across early childhoodRyann Tansey0Kirk Graff1Christiane S. Rohr2Dennis Dimond3Amanda Ip4Shelly Yin5Deborah Dewey6Signe Bray7Child and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Correspondence to: Alberta Children’s Hospital Research Institute, 28 Oki Drive NW, Calgary, AB T3B 6A8, Canada.Child and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, CanadaChild and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, CanadaChild and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, CanadaChild and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, CanadaChild and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, CanadaChild and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Community Health Science, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Owerko Centre at the Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, CanadaChild and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaWhile findings show that throughout development, there are child- and age-specific patterns of brain functioning, there is also evidence for significantly greater inter-individual response variability in young children relative to adults. It is currently unclear whether this increase in functional “typicality” (i.e., inter-individual similarity) is a developmental process that occurs across early childhood, and what changes in BOLD response may be driving changes in typicality. We collected fMRI data from 81 typically developing 4–8-year-old children during passive viewing of age-appropriate television clips and asked whether there is increasing typicality of brain response across this age range. We found that the “increasing typicality” hypothesis was supported across many regions engaged by passive viewing. Post hoc analyses showed that in a priori ROIs related to language and face processing, the strength of the group-average shared component of activity increased with age, with no concomitant decline in residual signal or change in spatial extent or variability. Together, this suggests that increasing inter-individual similarity of functional responses to audiovisual stimuli is an important feature of early childhood functional brain development.http://www.sciencedirect.com/science/article/pii/S1878929323000737 |
| spellingShingle | Ryann Tansey Kirk Graff Christiane S. Rohr Dennis Dimond Amanda Ip Shelly Yin Deborah Dewey Signe Bray Functional MRI responses to naturalistic stimuli are increasingly typical across early childhood Developmental Cognitive Neuroscience |
| title | Functional MRI responses to naturalistic stimuli are increasingly typical across early childhood |
| title_full | Functional MRI responses to naturalistic stimuli are increasingly typical across early childhood |
| title_fullStr | Functional MRI responses to naturalistic stimuli are increasingly typical across early childhood |
| title_full_unstemmed | Functional MRI responses to naturalistic stimuli are increasingly typical across early childhood |
| title_short | Functional MRI responses to naturalistic stimuli are increasingly typical across early childhood |
| title_sort | functional mri responses to naturalistic stimuli are increasingly typical across early childhood |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000737 |
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