Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function

Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function

The binding of the type 1 fimbrial adhesin FimH to mannosylated receptors is allosterically regulated to enhance the fitness of uropathogenic Escherichia coli (UPEC) during urinary tract infection (UTI). Mutations in the two FimH domains (pilin and lectin) located outside the mannose binding pocket...

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Bibliographic Details
Main Authors: Jilong Qin, Katie A. Wilson, Sohinee Sarkar, Begoña Heras, Megan L. O'Mara, Makrina Totsika
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
FimH adhesin
Protein allostery
Conformational equilibrium
ST131
Mannose
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003749

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