Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

The relationship between loss of hypothalamic function and onset of diabetes mellitus remains elusive. Therefore, we generated a targeted oxidative-stress murine model utilizing conditional knockout (KO) of selenocysteine-tRNA (Trsp) using rat-insulin-promoter-driven-Cre (RIP-Cre). These Trsp-KO (Tr...

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Bibliographic Details
Main Authors: Yoko Yagishita, Akira Uruno, Toshiaki Fukutomi, Ritsumi Saito, Daisuke Saigusa, Jingbo Pi, Akiyoshi Fukamizu, Fumihiro Sugiyama, Satoru Takahashi, Masayuki Yamamoto
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
Nrf2
oxidative stress
insulin resistance
leptin resistance
Trsp
selenoproteins
proopiomelanocortin
hypothalamus
pancreatic beta-cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301341

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