What have clinical trials taught us about brain health?
The Global Burden of Disease Study projects an almost tripling of dementia cases worldwide in the next 30 years making it important to recognize and understand modifiable risks and preventatives for cognitive impairment. Recent studies suggest that prevention or treatment of cardiovascular risks may...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cerebral Circulation - Cognition and Behavior |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666245023000430 |
| _version_ | 1797371355895693312 |
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| author | Keon-Joo Lee Hee-Joon Bae |
| author_facet | Keon-Joo Lee Hee-Joon Bae |
| author_sort | Keon-Joo Lee |
| collection | DOAJ |
| description | The Global Burden of Disease Study projects an almost tripling of dementia cases worldwide in the next 30 years making it important to recognize and understand modifiable risks and preventatives for cognitive impairment. Recent studies suggest that prevention or treatment of cardiovascular risks may be an important strategy to prevent or slow the progression of cognitive impairment. In 2017, the American Heart Association and American Stroke Association introduced metrics for ''optimal brain health''. These metrics defined brain health in terms of ideal health behaviors and factors.Since then and leading up to 2017, a number of clinical trials have been conducted to investigate the potential of modification of cardiovascular risks on prevention of dementia or cognitive impairment and thus, enhancement of brain health. This discussion is a review of findings from clinical trials focusing on interventions, including antihypertensive agents, glycemic control and lipid-lowering therapies, multidomain approaches, and antithrombotic medications. Notably, the results highlight the promise of intensive blood pressure lowering strategies and multidomain approaches, as evidenced by the FINGER trial. The review also discusses the potential of treatment or prevention of cerebral small vessel disease (cSVD) and the application of Mendelian randomization as a strategy to preserve brain structure and function. |
| first_indexed | 2024-03-08T18:18:37Z |
| format | Article |
| id | doaj.art-7a1bed8ec7984e489eddac67087c57dd |
| institution | Directory Open Access Journal |
| issn | 2666-2450 |
| language | English |
| last_indexed | 2024-03-08T18:18:37Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cerebral Circulation - Cognition and Behavior |
| spelling | doaj.art-7a1bed8ec7984e489eddac67087c57dd2023-12-31T04:28:01ZengElsevierCerebral Circulation - Cognition and Behavior2666-24502024-01-016100199What have clinical trials taught us about brain health?Keon-Joo Lee0Hee-Joon Bae1Department of Neurology, Korea University Guro Hospital, Seoul, South KoreaDepartment of Neurology and Cerebrovascular Center, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Corresponding author at: Department of Neurology and Cerebrovascular Center, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi—ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, South Korea.The Global Burden of Disease Study projects an almost tripling of dementia cases worldwide in the next 30 years making it important to recognize and understand modifiable risks and preventatives for cognitive impairment. Recent studies suggest that prevention or treatment of cardiovascular risks may be an important strategy to prevent or slow the progression of cognitive impairment. In 2017, the American Heart Association and American Stroke Association introduced metrics for ''optimal brain health''. These metrics defined brain health in terms of ideal health behaviors and factors.Since then and leading up to 2017, a number of clinical trials have been conducted to investigate the potential of modification of cardiovascular risks on prevention of dementia or cognitive impairment and thus, enhancement of brain health. This discussion is a review of findings from clinical trials focusing on interventions, including antihypertensive agents, glycemic control and lipid-lowering therapies, multidomain approaches, and antithrombotic medications. Notably, the results highlight the promise of intensive blood pressure lowering strategies and multidomain approaches, as evidenced by the FINGER trial. The review also discusses the potential of treatment or prevention of cerebral small vessel disease (cSVD) and the application of Mendelian randomization as a strategy to preserve brain structure and function.http://www.sciencedirect.com/science/article/pii/S2666245023000430Clinical trialsBrain healthMultidomain approachCerebral small vessel diseaseMendelian randomization |
| spellingShingle | Keon-Joo Lee Hee-Joon Bae What have clinical trials taught us about brain health? Cerebral Circulation - Cognition and Behavior Clinical trials Brain health Multidomain approach Cerebral small vessel disease Mendelian randomization |
| title | What have clinical trials taught us about brain health? |
| title_full | What have clinical trials taught us about brain health? |
| title_fullStr | What have clinical trials taught us about brain health? |
| title_full_unstemmed | What have clinical trials taught us about brain health? |
| title_short | What have clinical trials taught us about brain health? |
| title_sort | what have clinical trials taught us about brain health |
| topic | Clinical trials Brain health Multidomain approach Cerebral small vessel disease Mendelian randomization |
| url | http://www.sciencedirect.com/science/article/pii/S2666245023000430 |
| work_keys_str_mv | AT keonjoolee whathaveclinicaltrialstaughtusaboutbrainhealth AT heejoonbae whathaveclinicaltrialstaughtusaboutbrainhealth |