Melanoma Cells Produce Large Vesicular-Bodies That Cause Rapid Disruption of Brain Endothelial Barrier-Integrity and Disassembly of Junctional Proteins

Melanoma Cells Produce Large Vesicular-Bodies That Cause Rapid Disruption of Brain Endothelial Barrier-Integrity and Disassembly of Junctional Proteins

It is known that many cells produce extracellular vesicles, and this includes a range of different cancer cell types. Here we demonstrate the profound effects of large vesicular-like bodies produced by melanoma cells on the barrier integrity of human brain endothelial cells. These vesicular-bodies h...

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Bibliographic Details
Main Authors: Dayna Spurling, Akshata Anchan, James Hucklesby, Graeme Finlay, Catherine E. Angel, E. Scott Graham
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
brain endothelial cells
melanoma
brain metastasis
ECIS
oncosomes
apoptotic bodies
Online Access:https://www.mdpi.com/1422-0067/24/7/6082

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