Mutations of Recombinant Aquaporin-4 Antibody in the Fc Domain Can Impair Complement-Dependent Cellular Cytotoxicity and Transplacental Transport
Maternal antibodies provide protection for the developing fetus. Transplacental transport of pathogenic autoantibodies might pose a risk for the developing fetus. The transport of antibodies across the placenta to the fetal circulation occurs through the neonatal Fc salvage receptor (FcRn). During g...
Main Authors: | Simone Mader, Lior Brimberg, John N. Soltys, Jeffrey L. Bennett, Betty Diamond |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-07-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01599/full |
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