Mutations of Recombinant Aquaporin-4 Antibody in the Fc Domain Can Impair Complement-Dependent Cellular Cytotoxicity and Transplacental Transport

Mutations of Recombinant Aquaporin-4 Antibody in the Fc Domain Can Impair Complement-Dependent Cellular Cytotoxicity and Transplacental Transport

Maternal antibodies provide protection for the developing fetus. Transplacental transport of pathogenic autoantibodies might pose a risk for the developing fetus. The transport of antibodies across the placenta to the fetal circulation occurs through the neonatal Fc salvage receptor (FcRn). During g...

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Bibliographic Details
Main Authors: Simone Mader, Lior Brimberg, John N. Soltys, Jeffrey L. Bennett, Betty Diamond
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
maternal antibody
transplacental transport
FcRn
aquaporin-4 IgG
complement-dependent cytotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01599/full

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