Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention
ObjectiveTo determine whether the inclusion of white blood cell (WBC) counts in the SYNTAX score (SS) or SS II models could improve the models’ performance for risk stratification in individuals with chronic renal insufficiency (CRI) following percutaneous coronary intervention (PCI).MethodsIn total...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1027107/full |
| _version_ | 1811157757869424640 |
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| author | Wei Yan Wei Yan Mengyao Li Yumeng Lei Shuaiyong Zhang Fengfeng Lv Jiawang Wang Qian Yang Na Yu Ming Chen Xufen Cao Liqiu Yan Liqiu Yan |
| author_facet | Wei Yan Wei Yan Mengyao Li Yumeng Lei Shuaiyong Zhang Fengfeng Lv Jiawang Wang Qian Yang Na Yu Ming Chen Xufen Cao Liqiu Yan Liqiu Yan |
| author_sort | Wei Yan |
| collection | DOAJ |
| description | ObjectiveTo determine whether the inclusion of white blood cell (WBC) counts in the SYNTAX score (SS) or SS II models could improve the models’ performance for risk stratification in individuals with chronic renal insufficiency (CRI) following percutaneous coronary intervention (PCI).MethodsIn total, 2,313 patients with CRI, who were subjected to PCI and had data available on in-hospital WBC (ih-WBC) counts, were recruited. Patients were divided into 3 groups as per their ih-WBC counts (low, medium, and high). The primary endpoints were all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints incorporated myocardial infarction, stroke, unplanned revascularization, and major adverse cardiovascular and cerebrovascular events (MACCEs).ResultsDuring a median follow-up of 3 years, the high WBC group had the highest incidences of CM (2.4% vs. 2.1% vs. 6.7%; p < 0.001), ACM (6.3% vs. 4.1% vs. 8.2%; p < 0.001), unplanned revascularization (8.4% vs. 12.4% vs. 14.1%; p < 0.001), and MACCEs (19.3% vs. 23.0% vs. 29.2%; p < 0.001) among the three groups. Multivariable Cox regression analysis depicted that the risk of ACM and CM in the high WBC group was 2.577 (95% confidence interval [CI]: 1.504–4.415, p < 0.001) and 3.850 (95% CI: 1.835–8.080, p < 0.001) times that in the low WBC group after adjusting for other confounding factors. A combination of ih-WBC counts with SS or SS II significantly improved the risk assessment and prediction of ACM and CM.ConclusionThe ih-WBC counts was associated with the risk of occurrence of ACM, CM, unplanned revascularization, and MACCEs in individuals with CRI following PCI. It provides an incremental predictive value for the occurrence of ACM and CM when included in SS or SS II models. |
| first_indexed | 2024-04-10T05:11:37Z |
| format | Article |
| id | doaj.art-7a2277117b63416aa82a5a4dd896efd1 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T05:11:37Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-7a2277117b63416aa82a5a4dd896efd12023-03-09T07:08:18ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.10271071027107Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary interventionWei Yan0Wei Yan1Mengyao Li2Yumeng Lei3Shuaiyong Zhang4Fengfeng Lv5Jiawang Wang6Qian Yang7Na Yu8Ming Chen9Xufen Cao10Liqiu Yan11Liqiu Yan12Department of Cardiology and Dongguan Cardiovascular Research Institute, Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Cardiology and Dongguan Cardiovascular Research Institute, Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, ChinaDepartment of Cardiology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaObjectiveTo determine whether the inclusion of white blood cell (WBC) counts in the SYNTAX score (SS) or SS II models could improve the models’ performance for risk stratification in individuals with chronic renal insufficiency (CRI) following percutaneous coronary intervention (PCI).MethodsIn total, 2,313 patients with CRI, who were subjected to PCI and had data available on in-hospital WBC (ih-WBC) counts, were recruited. Patients were divided into 3 groups as per their ih-WBC counts (low, medium, and high). The primary endpoints were all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints incorporated myocardial infarction, stroke, unplanned revascularization, and major adverse cardiovascular and cerebrovascular events (MACCEs).ResultsDuring a median follow-up of 3 years, the high WBC group had the highest incidences of CM (2.4% vs. 2.1% vs. 6.7%; p < 0.001), ACM (6.3% vs. 4.1% vs. 8.2%; p < 0.001), unplanned revascularization (8.4% vs. 12.4% vs. 14.1%; p < 0.001), and MACCEs (19.3% vs. 23.0% vs. 29.2%; p < 0.001) among the three groups. Multivariable Cox regression analysis depicted that the risk of ACM and CM in the high WBC group was 2.577 (95% confidence interval [CI]: 1.504–4.415, p < 0.001) and 3.850 (95% CI: 1.835–8.080, p < 0.001) times that in the low WBC group after adjusting for other confounding factors. A combination of ih-WBC counts with SS or SS II significantly improved the risk assessment and prediction of ACM and CM.ConclusionThe ih-WBC counts was associated with the risk of occurrence of ACM, CM, unplanned revascularization, and MACCEs in individuals with CRI following PCI. It provides an incremental predictive value for the occurrence of ACM and CM when included in SS or SS II models.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1027107/fullwhite blood cell countSYNTAX scoreSYNTAX score IIchronic renal insufficiencypercutaneous coronary intervention |
| spellingShingle | Wei Yan Wei Yan Mengyao Li Yumeng Lei Shuaiyong Zhang Fengfeng Lv Jiawang Wang Qian Yang Na Yu Ming Chen Xufen Cao Liqiu Yan Liqiu Yan Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention Frontiers in Cardiovascular Medicine white blood cell count SYNTAX score SYNTAX score II chronic renal insufficiency percutaneous coronary intervention |
| title | Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention |
| title_full | Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention |
| title_fullStr | Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention |
| title_full_unstemmed | Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention |
| title_short | Prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention |
| title_sort | prognostic impact of white blood cell counts on clinical outcomes in patients with chronic renal insufficiency undergoing percutaneous coronary intervention |
| topic | white blood cell count SYNTAX score SYNTAX score II chronic renal insufficiency percutaneous coronary intervention |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1027107/full |
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