Molecular Epidemiology of Rift Valley Fever Virus

Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944–2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn g...

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Bibliographic Details
Main Authors: Antoinette A. Grobbelaar, Jacqueline Weyer, Patricia A. Leman, Alan Kemp, Janusz T. Paweska, Robert Swanepoel
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2011-12-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/17/12/11-1035_article
Description
Summary:Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944–2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.
ISSN:1080-6040
1080-6059