Fentanyl-induced respiratory depression is attenuated in pregnant patients
Xiaofei Cao,* Shijiang Liu,* Jie Sun, Min Yu, Yin Fang, Zhengnian Ding Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China *These authors contributed equally to this work Background: Respiratory depression is a complication o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-11-01
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| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/fentanyl-induced-respiratory-depression-is-attenuated-in-pregnant-pati-peer-reviewed-article-DDDT |
| _version_ | 1818133890001272832 |
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| author | Cao X Liu S Sun J Yu M Fang Y Ding Z |
| author_facet | Cao X Liu S Sun J Yu M Fang Y Ding Z |
| author_sort | Cao X |
| collection | DOAJ |
| description | Xiaofei Cao,* Shijiang Liu,* Jie Sun, Min Yu, Yin Fang, Zhengnian Ding Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China *These authors contributed equally to this work Background: Respiratory depression is a complication of intravenous fentanyl administration. The effect of pregnancy on respiratory depression following opioid administration is unclear. This study investigated the effect of pregnancy on fentanyl-induced respiratory depression.Patients and methods: Female patients were divided into three groups (n=20 per group): control group (non-pregnant and scheduled for laparoscopic surgery), early pregnancy group (pregnant for 45–60 days and scheduled for abortion), and postpartum group (5–7 days postpartum scheduled for complete curettage of uterine cavity). All patients received an intravenous infusion of fentanyl 2 µg/kg. Respiratory rate (RR), end-tidal pressure of carbon dioxide (PETCO2), and pulse oxygen saturation (SpO2) were recorded continuously from just before fentanyl infusion to 15 min after commencing infusion. Plasma levels of progesterone were measured.Results: SpO2 levels in the early pregnancy and postpartum groups were significantly higher and the levels of RR and PETCO2 were significantly lower than the control group. RR and SpO2 levels were significantly decreased in all groups, whereas PETCO2 was significantly increased after fentanyl infusion. The rates of RR increase and SpO2 decrease were significantly faster in the control group than in the other groups. The lowest SpO2 after intravenous fentanyl administration was significantly positively correlated with plasma progesterone levels.Conclusion: Pregnancy improves fentanyl-induced respiratory depression, which may be associated with the increased levels of plasma progesterone. Keywords: fentanyl, pregnancy, respiratory depression, progesterone |
| first_indexed | 2024-12-11T08:59:54Z |
| format | Article |
| id | doaj.art-7a271e6a1c15412088da9662ee4e28c0 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-11T08:59:54Z |
| publishDate | 2017-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-7a271e6a1c15412088da9662ee4e28c02022-12-22T01:13:48ZengDove Medical PressDrug Design, Development and Therapy1177-88812017-11-01Volume 113325333235688Fentanyl-induced respiratory depression is attenuated in pregnant patientsCao XLiu SSun JYu MFang YDing ZXiaofei Cao,* Shijiang Liu,* Jie Sun, Min Yu, Yin Fang, Zhengnian Ding Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China *These authors contributed equally to this work Background: Respiratory depression is a complication of intravenous fentanyl administration. The effect of pregnancy on respiratory depression following opioid administration is unclear. This study investigated the effect of pregnancy on fentanyl-induced respiratory depression.Patients and methods: Female patients were divided into three groups (n=20 per group): control group (non-pregnant and scheduled for laparoscopic surgery), early pregnancy group (pregnant for 45–60 days and scheduled for abortion), and postpartum group (5–7 days postpartum scheduled for complete curettage of uterine cavity). All patients received an intravenous infusion of fentanyl 2 µg/kg. Respiratory rate (RR), end-tidal pressure of carbon dioxide (PETCO2), and pulse oxygen saturation (SpO2) were recorded continuously from just before fentanyl infusion to 15 min after commencing infusion. Plasma levels of progesterone were measured.Results: SpO2 levels in the early pregnancy and postpartum groups were significantly higher and the levels of RR and PETCO2 were significantly lower than the control group. RR and SpO2 levels were significantly decreased in all groups, whereas PETCO2 was significantly increased after fentanyl infusion. The rates of RR increase and SpO2 decrease were significantly faster in the control group than in the other groups. The lowest SpO2 after intravenous fentanyl administration was significantly positively correlated with plasma progesterone levels.Conclusion: Pregnancy improves fentanyl-induced respiratory depression, which may be associated with the increased levels of plasma progesterone. Keywords: fentanyl, pregnancy, respiratory depression, progesterone https://www.dovepress.com/fentanyl-induced-respiratory-depression-is-attenuated-in-pregnant-pati-peer-reviewed-article-DDDTFentanylPregnancyRespiratory depressionProgesterone |
| spellingShingle | Cao X Liu S Sun J Yu M Fang Y Ding Z Fentanyl-induced respiratory depression is attenuated in pregnant patients Drug Design, Development and Therapy Fentanyl Pregnancy Respiratory depression Progesterone |
| title | Fentanyl-induced respiratory depression is attenuated in pregnant patients |
| title_full | Fentanyl-induced respiratory depression is attenuated in pregnant patients |
| title_fullStr | Fentanyl-induced respiratory depression is attenuated in pregnant patients |
| title_full_unstemmed | Fentanyl-induced respiratory depression is attenuated in pregnant patients |
| title_short | Fentanyl-induced respiratory depression is attenuated in pregnant patients |
| title_sort | fentanyl induced respiratory depression is attenuated in pregnant patients |
| topic | Fentanyl Pregnancy Respiratory depression Progesterone |
| url | https://www.dovepress.com/fentanyl-induced-respiratory-depression-is-attenuated-in-pregnant-pati-peer-reviewed-article-DDDT |
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