Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates
Viral templates are highly versatile biotemplates used for the synthesis of nanostructured materials. Rotavirus VP6 self-assembles into nanotubular hollow structures with well-defined diameters and variable lengths, serving as a nucleic acid-free biotemplate to synthesize metal nanoparticles of cont...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-08-01
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| Series: | Metals |
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| Online Access: | http://www.mdpi.com/2075-4701/6/9/200 |
| _version_ | 1818318351790768128 |
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| author | Liliana Carreño-Fuentes Daniel Bahena Laura A. Palomares Octavio T. Ramírez Miguel José-Yacamán Germán Plascencia-Villa |
| author_facet | Liliana Carreño-Fuentes Daniel Bahena Laura A. Palomares Octavio T. Ramírez Miguel José-Yacamán Germán Plascencia-Villa |
| author_sort | Liliana Carreño-Fuentes |
| collection | DOAJ |
| description | Viral templates are highly versatile biotemplates used for the synthesis of nanostructured materials. Rotavirus VP6 self-assembles into nanotubular hollow structures with well-defined diameters and variable lengths, serving as a nucleic acid-free biotemplate to synthesize metal nanoparticles of controlled size, shape, and orientation. Molecular docking simulations show that exposed residues (H173-S240-D242 and N200-N310) of VP6 have the ability to specifically bind Pd(II) ions, which serve as nucleation sites for the growth and stabilization of palladium nanoclusters. Using VP6 nanotubes as biotemplates allows for obtaining small Pd particles of 1–5 nm in diameter. Advanced electron microscopy imaging and characterization through ultra-high-resolution field-emission scanning electron microscopy (UHR-FE-SEM) and spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM) at a low voltage dose (80 kV) reveals, with high spatial resolution, the structure of Pd nanoparticles attached to the macromolecular biotemplates. |
| first_indexed | 2024-12-13T09:51:51Z |
| format | Article |
| id | doaj.art-7a287f585aaf4db3a3d888b78e164b86 |
| institution | Directory Open Access Journal |
| issn | 2075-4701 |
| language | English |
| last_indexed | 2024-12-13T09:51:51Z |
| publishDate | 2016-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metals |
| spelling | doaj.art-7a287f585aaf4db3a3d888b78e164b862022-12-21T23:51:54ZengMDPI AGMetals2075-47012016-08-016920010.3390/met6090200met6090200Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral TemplatesLiliana Carreño-Fuentes0Daniel Bahena1Laura A. Palomares2Octavio T. Ramírez3Miguel José-Yacamán4Germán Plascencia-Villa5Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología UNAM, Cuernavaca Morelos 62210, MexicoCINVESTAV Zacatenco, México City 07360, MexicoDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología UNAM, Cuernavaca Morelos 62210, MexicoDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología UNAM, Cuernavaca Morelos 62210, MexicoDepartment of Physics and Astronomy, Research Centers in Minority Institutions (RCMI), The University of Texas at San Antonio (UTSA), San Antonio, TX 78249, USADepartment of Physics and Astronomy, Research Centers in Minority Institutions (RCMI), The University of Texas at San Antonio (UTSA), San Antonio, TX 78249, USAViral templates are highly versatile biotemplates used for the synthesis of nanostructured materials. Rotavirus VP6 self-assembles into nanotubular hollow structures with well-defined diameters and variable lengths, serving as a nucleic acid-free biotemplate to synthesize metal nanoparticles of controlled size, shape, and orientation. Molecular docking simulations show that exposed residues (H173-S240-D242 and N200-N310) of VP6 have the ability to specifically bind Pd(II) ions, which serve as nucleation sites for the growth and stabilization of palladium nanoclusters. Using VP6 nanotubes as biotemplates allows for obtaining small Pd particles of 1–5 nm in diameter. Advanced electron microscopy imaging and characterization through ultra-high-resolution field-emission scanning electron microscopy (UHR-FE-SEM) and spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM) at a low voltage dose (80 kV) reveals, with high spatial resolution, the structure of Pd nanoparticles attached to the macromolecular biotemplates.http://www.mdpi.com/2075-4701/6/9/200proteinsviruspalladium nanoparticlesadvanced electron microscopymolecular docking |
| spellingShingle | Liliana Carreño-Fuentes Daniel Bahena Laura A. Palomares Octavio T. Ramírez Miguel José-Yacamán Germán Plascencia-Villa Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates Metals proteins virus palladium nanoparticles advanced electron microscopy molecular docking |
| title | Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates |
| title_full | Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates |
| title_fullStr | Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates |
| title_full_unstemmed | Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates |
| title_short | Molecular Docking and Aberration-Corrected STEM of Palladium Nanoparticles on Viral Templates |
| title_sort | molecular docking and aberration corrected stem of palladium nanoparticles on viral templates |
| topic | proteins virus palladium nanoparticles advanced electron microscopy molecular docking |
| url | http://www.mdpi.com/2075-4701/6/9/200 |
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