Advances on immunotoxicities induced by per- and polyfluoroalkylated substances
Per-and polyfluoroalkylated substances (PFASs) are a group of persistent organic pollutants that are widespread in the environment and organisms. Given their unique hydrophobicity, oil-repellence, and chemical stability, PFASs are widely used in various industrial and commercial products. PFASs can...
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2022-02-01
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| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM21237 |
| _version_ | 1828408539323826176 |
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| author | Minyan CHEN Zixia WANG Ying TIAN Yu GAO |
| author_facet | Minyan CHEN Zixia WANG Ying TIAN Yu GAO |
| author_sort | Minyan CHEN |
| collection | DOAJ |
| description | Per-and polyfluoroalkylated substances (PFASs) are a group of persistent organic pollutants that are widespread in the environment and organisms. Given their unique hydrophobicity, oil-repellence, and chemical stability, PFASs are widely used in various industrial and commercial products. PFASs can accumulate and be biomagnified through the food chain, and its toxic effects have posed a certain threat to human health. The response of the immune system to PFASs exposure is one of the most sensitive human health effects, and has attracted remarkable attention from related scientists and organizations. We summarized international and domestic epidemiological studies on the associations between exposure to PFASs and immune system, including immunosuppression and immunoenhancement. We also reviewed experimental evidence of PFASs on immune system from perspectives of immune organs, immune cells, and cytokines. Furthermore, the possible mechanisms of peroxisome proliferator-activated receptor-α (PPAR-α)-dependent, nuclear factor-κB (NF-κB)-activated, and mitochondrial apoptosis pathways were summarized. While the relationships between PFASs and immune-related diseases in human are not yet conclusive, accumulative epidemiological studies provide evidence for associations between PFASs and reduced immune response to vaccination in children. In addition, previous studies mainly focus on the immunotoxicity of traditional PFASs, and our understanding of the molecular mechanism of the effects of PFASs on immune system is still in its infancy. Therefore, it is necessary to further explore the immunotoxicity of new PFASs and associated mechanism. |
| first_indexed | 2024-12-10T11:41:01Z |
| format | Article |
| id | doaj.art-7a28e4d3728f408bb4ad3c21cd5a38eb |
| institution | Directory Open Access Journal |
| issn | 2095-9982 |
| language | English |
| last_indexed | 2024-12-10T11:41:01Z |
| publishDate | 2022-02-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj.art-7a28e4d3728f408bb4ad3c21cd5a38eb2022-12-22T01:50:15ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822022-02-0139222322810.11836/JEOM2123721237Advances on immunotoxicities induced by per- and polyfluoroalkylated substancesMinyan CHEN0Zixia WANG1Ying TIAN2Yu GAO3Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaPer-and polyfluoroalkylated substances (PFASs) are a group of persistent organic pollutants that are widespread in the environment and organisms. Given their unique hydrophobicity, oil-repellence, and chemical stability, PFASs are widely used in various industrial and commercial products. PFASs can accumulate and be biomagnified through the food chain, and its toxic effects have posed a certain threat to human health. The response of the immune system to PFASs exposure is one of the most sensitive human health effects, and has attracted remarkable attention from related scientists and organizations. We summarized international and domestic epidemiological studies on the associations between exposure to PFASs and immune system, including immunosuppression and immunoenhancement. We also reviewed experimental evidence of PFASs on immune system from perspectives of immune organs, immune cells, and cytokines. Furthermore, the possible mechanisms of peroxisome proliferator-activated receptor-α (PPAR-α)-dependent, nuclear factor-κB (NF-κB)-activated, and mitochondrial apoptosis pathways were summarized. While the relationships between PFASs and immune-related diseases in human are not yet conclusive, accumulative epidemiological studies provide evidence for associations between PFASs and reduced immune response to vaccination in children. In addition, previous studies mainly focus on the immunotoxicity of traditional PFASs, and our understanding of the molecular mechanism of the effects of PFASs on immune system is still in its infancy. Therefore, it is necessary to further explore the immunotoxicity of new PFASs and associated mechanism.http://www.jeom.org/article/cn/10.11836/JEOM21237per- and polyfluoroalkylated substancesimmune toxicityimmunosuppressioncytokinemechanism |
| spellingShingle | Minyan CHEN Zixia WANG Ying TIAN Yu GAO Advances on immunotoxicities induced by per- and polyfluoroalkylated substances 环境与职业医学 per- and polyfluoroalkylated substances immune toxicity immunosuppression cytokine mechanism |
| title | Advances on immunotoxicities induced by per- and polyfluoroalkylated substances |
| title_full | Advances on immunotoxicities induced by per- and polyfluoroalkylated substances |
| title_fullStr | Advances on immunotoxicities induced by per- and polyfluoroalkylated substances |
| title_full_unstemmed | Advances on immunotoxicities induced by per- and polyfluoroalkylated substances |
| title_short | Advances on immunotoxicities induced by per- and polyfluoroalkylated substances |
| title_sort | advances on immunotoxicities induced by per and polyfluoroalkylated substances |
| topic | per- and polyfluoroalkylated substances immune toxicity immunosuppression cytokine mechanism |
| url | http://www.jeom.org/article/cn/10.11836/JEOM21237 |
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