MicroRNA Expression in Cystic Fibrosis Airway Epithelium
MicroRNAs (miRs) have emerged as major regulators of the protein content of a cell. In the most part, miRs negatively regulate target mRNA expression, with sets of miRs predicted to regulate certain signaling pathways. The miR expression profile of endobronchial brushings is altered in people with c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-02-01
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| Series: | Biomolecules |
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| Online Access: | http://www.mdpi.com/2218-273X/3/1/157 |
| _version_ | 1819243640346640384 |
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| author | Catherine M. Greene |
| author_facet | Catherine M. Greene |
| author_sort | Catherine M. Greene |
| collection | DOAJ |
| description | MicroRNAs (miRs) have emerged as major regulators of the protein content of a cell. In the most part, miRs negatively regulate target mRNA expression, with sets of miRs predicted to regulate certain signaling pathways. The miR expression profile of endobronchial brushings is altered in people with cystic fibrosis (CF) compared to those without CF. How this impacts on CF has important implications for our growing understanding of the pathophysiology of CF lung disease and the development of new therapeutics to treat its pulmonary manifestations. Herein we discuss the potential consequences of altered miR expression in CF airway epithelium particularly with respect to cystic fibrosis transmembrane conductance regulator (CFTR) expression, innate immunity and toll-like receptor signalling and explore how best to exploit these changes for therapeutic benefit. |
| first_indexed | 2024-12-23T14:58:55Z |
| format | Article |
| id | doaj.art-7a2947cd734a47ce88b39a7fbdbf5658 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-23T14:58:55Z |
| publishDate | 2013-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-7a2947cd734a47ce88b39a7fbdbf56582022-12-21T17:42:40ZengMDPI AGBiomolecules2218-273X2013-02-013115716710.3390/biom3010157MicroRNA Expression in Cystic Fibrosis Airway EpitheliumCatherine M. GreeneMicroRNAs (miRs) have emerged as major regulators of the protein content of a cell. In the most part, miRs negatively regulate target mRNA expression, with sets of miRs predicted to regulate certain signaling pathways. The miR expression profile of endobronchial brushings is altered in people with cystic fibrosis (CF) compared to those without CF. How this impacts on CF has important implications for our growing understanding of the pathophysiology of CF lung disease and the development of new therapeutics to treat its pulmonary manifestations. Herein we discuss the potential consequences of altered miR expression in CF airway epithelium particularly with respect to cystic fibrosis transmembrane conductance regulator (CFTR) expression, innate immunity and toll-like receptor signalling and explore how best to exploit these changes for therapeutic benefit.http://www.mdpi.com/2218-273X/3/1/157cystic fibrosisairway epitheliummicroRNA |
| spellingShingle | Catherine M. Greene MicroRNA Expression in Cystic Fibrosis Airway Epithelium Biomolecules cystic fibrosis airway epithelium microRNA |
| title | MicroRNA Expression in Cystic Fibrosis Airway Epithelium |
| title_full | MicroRNA Expression in Cystic Fibrosis Airway Epithelium |
| title_fullStr | MicroRNA Expression in Cystic Fibrosis Airway Epithelium |
| title_full_unstemmed | MicroRNA Expression in Cystic Fibrosis Airway Epithelium |
| title_short | MicroRNA Expression in Cystic Fibrosis Airway Epithelium |
| title_sort | microrna expression in cystic fibrosis airway epithelium |
| topic | cystic fibrosis airway epithelium microRNA |
| url | http://www.mdpi.com/2218-273X/3/1/157 |
| work_keys_str_mv | AT catherinemgreene micrornaexpressionincysticfibrosisairwayepithelium |