Screening of Biomarkers and Toxicity Mechanisms of Rifampicin-Induced Liver Injury Based on Targeted Bile Acid Metabolomics
Rifampicin (RIF) is a critical first-line drug for tuberculosis. However, long-term or high-dose treatment with RIF can induce severe liver injury; the underlying mechanism of this effect has not yet been clarified. This study was performed to screen reliable and sensitive biomarkers in serum bile a...
Main Authors: | Yang Deng, Xilin Luo, Xin Li, Yisha Xiao, Bing Xu, Huan Tong |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-06-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.925509/full |
Similar Items
-
Regulation of bile acids and their receptor FXR in metabolic diseases
by: Yao Li, et al.
Published: (2024-12-01) -
Bile Acids and Their Value for Central Nervous System
by: Yu. O. Shulpekova, et al.
Published: (2022-01-01) -
Importance of gut microbiota for bile acid composition and concentration in pigs
by: Jing Sun, et al.
Published: (2022-08-01) -
Evaluation of the genexpert Mycobacterium tuberculosis/Rifampicin assay for early detection of extrapulmonary tuberculosis and rifampicin resistance in aligarh region of Northern India
by: M D Ahsan Imam, et al.
Published: (2023-01-01) -
Decreased mortality seen in rifampicin/multidrug-resistant tuberculous meningitis treated with linezolid in Shenzhen, China
by: Mu-Tong Fang, et al.
Published: (2021-09-01)