Research Progress in Genomics of Lumpy Skin Disease Virus

Lumpy skin disease(LSD) is an animal infectious disease caused by Lumpy Skin Disease Virus(LSDV) that produces nodular lesions in cattle, and is widespread in East, South and Southeast Asian countries, causing serious economic losses to the local cattle industry. Currently, LSD is managed as a secon...

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Main Authors: Qi ZHAI, Minxia HUANG, Dianhong LYU, Chunling JIA, Xiurong ZHOU, Xiaohui WEN, Shengjun LUO
Format: Article
Language:English
Published: Guangdong Academy of Agricultural Sciences 2022-07-01
Series:Guangdong nongye kexue
Subjects:
Online Access:http://gdnykx.cnjournals.org/gdnykx/ch/reader/view_abstract.aspx?file_no=202207013
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author Qi ZHAI
Minxia HUANG
Dianhong LYU
Chunling JIA
Xiurong ZHOU
Xiaohui WEN
Shengjun LUO
author_facet Qi ZHAI
Minxia HUANG
Dianhong LYU
Chunling JIA
Xiurong ZHOU
Xiaohui WEN
Shengjun LUO
author_sort Qi ZHAI
collection DOAJ
description Lumpy skin disease(LSD) is an animal infectious disease caused by Lumpy Skin Disease Virus(LSDV) that produces nodular lesions in cattle, and is widespread in East, South and Southeast Asian countries, causing serious economic losses to the local cattle industry. Currently, LSD is managed as a second-class animal disease in China. Since 2019, more than ten provinces in China have reported LSD epidemics, whose situation is very serious. At present, the superior cell for LSDV isolation and proliferation is Madin-Darby bovine kidney(MDBK). As a member of the Goat Pox Virus genus of the Poxviridae family, LSDV has a virus particle diameter about 290 nm × 270 nm, with two existence forms. The viral genome is complex and huge, about 151 kb, and contains more than 150 genes. Currently, only approximately 40 LSDV strains containing the whole genome sequence information are stored in the GenBank database. In addition to field wild strains, recombinant strains of field wild strains and vaccine strains have also emerged in some parts of Asia in recent years, and the prevalent recombinant strains are pathogenic, which poses new challenges for development of vaccine and preparation of prevention and control strategies for LSD in the future. The study mainly summarizes the etiology of LSD and the progress in the genome-wide study of LSDV strains in different regions of Africa, Europe and Asia, with a view to providing references for the prevention and control of LSD and further researches.
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spelling doaj.art-7a2af691fde940a6a50ab01a0125c14c2023-06-16T06:41:31ZengGuangdong Academy of Agricultural SciencesGuangdong nongye kexue1004-874X2022-07-014979710410.16768/j.issn.1004-874X.2022.07.013202207013Research Progress in Genomics of Lumpy Skin Disease VirusQi ZHAI0Minxia HUANG1Dianhong LYU2Chunling JIA3Xiurong ZHOU4Xiaohui WEN5Shengjun LUO6Institute of Animal Health, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention, Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques, Ministry of Agriculture and Rural Affairs Guangzhou 510640, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention, Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques, Ministry of Agriculture and Rural Affairs Guangzhou 510640, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention, Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques, Ministry of Agriculture and Rural Affairs Guangzhou 510640, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention, Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques, Ministry of Agriculture and Rural Affairs Guangzhou 510640, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention, Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques, Ministry of Agriculture and Rural Affairs Guangzhou 510640, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention, Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques, Ministry of Agriculture and Rural Affairs Guangzhou 510640, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention, Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques, Ministry of Agriculture and Rural Affairs Guangzhou 510640, ChinaLumpy skin disease(LSD) is an animal infectious disease caused by Lumpy Skin Disease Virus(LSDV) that produces nodular lesions in cattle, and is widespread in East, South and Southeast Asian countries, causing serious economic losses to the local cattle industry. Currently, LSD is managed as a second-class animal disease in China. Since 2019, more than ten provinces in China have reported LSD epidemics, whose situation is very serious. At present, the superior cell for LSDV isolation and proliferation is Madin-Darby bovine kidney(MDBK). As a member of the Goat Pox Virus genus of the Poxviridae family, LSDV has a virus particle diameter about 290 nm × 270 nm, with two existence forms. The viral genome is complex and huge, about 151 kb, and contains more than 150 genes. Currently, only approximately 40 LSDV strains containing the whole genome sequence information are stored in the GenBank database. In addition to field wild strains, recombinant strains of field wild strains and vaccine strains have also emerged in some parts of Asia in recent years, and the prevalent recombinant strains are pathogenic, which poses new challenges for development of vaccine and preparation of prevention and control strategies for LSD in the future. The study mainly summarizes the etiology of LSD and the progress in the genome-wide study of LSDV strains in different regions of Africa, Europe and Asia, with a view to providing references for the prevention and control of LSD and further researches.http://gdnykx.cnjournals.org/gdnykx/ch/reader/view_abstract.aspx?file_no=202207013lumpy skin disease virus(lsdv)etiologygenomicssequencingrecombinant strain
spellingShingle Qi ZHAI
Minxia HUANG
Dianhong LYU
Chunling JIA
Xiurong ZHOU
Xiaohui WEN
Shengjun LUO
Research Progress in Genomics of Lumpy Skin Disease Virus
Guangdong nongye kexue
lumpy skin disease virus(lsdv)
etiology
genomics
sequencing
recombinant strain
title Research Progress in Genomics of Lumpy Skin Disease Virus
title_full Research Progress in Genomics of Lumpy Skin Disease Virus
title_fullStr Research Progress in Genomics of Lumpy Skin Disease Virus
title_full_unstemmed Research Progress in Genomics of Lumpy Skin Disease Virus
title_short Research Progress in Genomics of Lumpy Skin Disease Virus
title_sort research progress in genomics of lumpy skin disease virus
topic lumpy skin disease virus(lsdv)
etiology
genomics
sequencing
recombinant strain
url http://gdnykx.cnjournals.org/gdnykx/ch/reader/view_abstract.aspx?file_no=202207013
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AT xiurongzhou researchprogressingenomicsoflumpyskindiseasevirus
AT xiaohuiwen researchprogressingenomicsoflumpyskindiseasevirus
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