Knockdown of YAP inhibits growth in Hep-2 laryngeal cancer cells via epithelial-mesenchymal transition and the Wnt/β-catenin pathway

Knockdown of YAP inhibits growth in Hep-2 laryngeal cancer cells via epithelial-mesenchymal transition and the Wnt/β-catenin pathway

Abstract Background Yes-associated protein (YAP) plays a crucial role in tumour development and it is the main effector of the Hippo signalling pathway. However, the mechanism underlying YAP downregulation in laryngeal cancer is still unclear. In our previous study, we found that YAP, compared with...

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Bibliographic Details
Main Authors: Xiaomin Tang, Yuxuan Sun, Ganglun Wan, Jiaqiang Sun, Jingwu Sun, Chunchen Pan
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
YAP
laryngeal cancer
Wnt/β-catenin
Hep-2
EMT
Online Access:http://link.springer.com/article/10.1186/s12885-019-5832-9

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