Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context
Summary: Background: Endovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with large infarction. Revealing subgroups of patients who would or would not benefit from EVT will further inform patient selection for EVT. Methods: This post-hoc analysis of the ANGEL...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537024001743 |
| _version_ | 1827284848027369472 |
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| author | Lina Zheng Ximing Nie Mengxing Wang Xin Liu Wanying Duan Zhe Zhang Jingyi Liu Yufei Wei Miao Wen Zhonghua Yang Thomas W. Leung Gaoting Ma Xiaochuan Huo Yuesong Pan Thanh N. Nguyen Xinyi Leng Zhongrong Miao Liping Liu Yongjun Wang Yilong Wang Liping Liu David S. Liebeskind Zhongrong Miao Zeguang Ren Vitor Mendes Pereira Xunming Ji Qiang Dong Anding Xu Xinfeng Liu Qingwu Yang Jing Jing (Chair) Zhe Zhang Yingkui Zhang Wei Wu Dapeng Sun Zhongqi Qi Shuo Li Zhenqiang Liu Zequan Yu Jingyu Zhang Fangguang Chen Kangyue Li Kai Zhang Mingkai Hu Jianmin Liu (Chair) Chen Yao Kangning Chen Kun Fang (Chair) Bo Song Yi Dong Zhongrong Miao Xiaochuan Huo Gaoting Ma Guangxiong Yuan Hongxing Han Wenhuo Chen Ming Wei Jiangang Zhang Zhiming Zhou Xiaoxi Yao Guoqing Wang Weigen Song Xueli Cai Guangxian Nan Di Li Yizhou Wang Wentong Ling Chuwei Cai Changming Wen En Wang Liyong Zhang Changchun Jiang Yajie Liu Geng Liao Xiaohui Chen Tianxiao Li Shudong Liu Jinglun Li Yaxuan Sun Na Xu Zong’en Gao Dongsheng Ju Cunfeng Song Jinggang Xuan Feng Zhou Qing Shi Jun Luo Yan Liu Zaiyu Guo Tong Li Hongbo Zheng Linzhi Dai Junfeng Zhao Liqiang Gui Xiaokun Geng Yufeng Tang Congguo Yin Hua Yang Xiaochuan Huo Gaoting Ma Ruiyang An Yuying Sun Yanan Wu Chunlai Yu Shuangcheng Zheng Yuesong Pan Aoming Jin Xianglong Xiang Mengxing Wang Hongyi Yan Yuanling He Chunyang Li Weixia Kong Yuhuan Chen Chenhao Guo Fengjie Ji Pengshan Ji Lei Liu Xinghua Lu Guangkuo Luo Nanjing Wang Yu Zhang Bo Liu Jian Yang Jingjing Deng Juan Wang Wanru Wang Hang Yu Le Cui Wenwen Liu Ziyong Wang Xia Zhao Zhou Zhou Zhongrong Miao Guangxiong Yuan Hongxing Han Wenhuo Chen Ming Wei Jiangang Zhang Zhiming Zhou Xiaoxi Yao Guoqing Wang Weigen Song Xueli Cai Guangxian Nan Di Li Alvin Yi-Chou Wang Wentong Ling Chuwei Cai Changming Wen En Wang Liyong Zhang Changchun Jiang Yajie Liu Geng Liao Xiaohui Chen Tianxiao Li Shudong Liu Jinglun Li Yaxuan Sun Na Xu Zong’en Gao Dongsheng Ju Cunfeng Song Jinggang Xuan Feng Zhou Qing Shi Jun Luo Yan Liu Zaiyu Guo Tong Li Hongbo Zheng Linzhi Dai Junfeng Zhao Liqiang Gui Xiaokun Geng Yufeng Tang Congguo Yin Hua Yang |
| author_facet | Lina Zheng Ximing Nie Mengxing Wang Xin Liu Wanying Duan Zhe Zhang Jingyi Liu Yufei Wei Miao Wen Zhonghua Yang Thomas W. Leung Gaoting Ma Xiaochuan Huo Yuesong Pan Thanh N. Nguyen Xinyi Leng Zhongrong Miao Liping Liu Yongjun Wang Yilong Wang Liping Liu David S. Liebeskind Zhongrong Miao Zeguang Ren Vitor Mendes Pereira Xunming Ji Qiang Dong Anding Xu Xinfeng Liu Qingwu Yang Jing Jing (Chair) Zhe Zhang Yingkui Zhang Wei Wu Dapeng Sun Zhongqi Qi Shuo Li Zhenqiang Liu Zequan Yu Jingyu Zhang Fangguang Chen Kangyue Li Kai Zhang Mingkai Hu Jianmin Liu (Chair) Chen Yao Kangning Chen Kun Fang (Chair) Bo Song Yi Dong Zhongrong Miao Xiaochuan Huo Gaoting Ma Guangxiong Yuan Hongxing Han Wenhuo Chen Ming Wei Jiangang Zhang Zhiming Zhou Xiaoxi Yao Guoqing Wang Weigen Song Xueli Cai Guangxian Nan Di Li Yizhou Wang Wentong Ling Chuwei Cai Changming Wen En Wang Liyong Zhang Changchun Jiang Yajie Liu Geng Liao Xiaohui Chen Tianxiao Li Shudong Liu Jinglun Li Yaxuan Sun Na Xu Zong’en Gao Dongsheng Ju Cunfeng Song Jinggang Xuan Feng Zhou Qing Shi Jun Luo Yan Liu Zaiyu Guo Tong Li Hongbo Zheng Linzhi Dai Junfeng Zhao Liqiang Gui Xiaokun Geng Yufeng Tang Congguo Yin Hua Yang Xiaochuan Huo Gaoting Ma Ruiyang An Yuying Sun Yanan Wu Chunlai Yu Shuangcheng Zheng Yuesong Pan Aoming Jin Xianglong Xiang Mengxing Wang Hongyi Yan Yuanling He Chunyang Li Weixia Kong Yuhuan Chen Chenhao Guo Fengjie Ji Pengshan Ji Lei Liu Xinghua Lu Guangkuo Luo Nanjing Wang Yu Zhang Bo Liu Jian Yang Jingjing Deng Juan Wang Wanru Wang Hang Yu Le Cui Wenwen Liu Ziyong Wang Xia Zhao Zhou Zhou Zhongrong Miao Guangxiong Yuan Hongxing Han Wenhuo Chen Ming Wei Jiangang Zhang Zhiming Zhou Xiaoxi Yao Guoqing Wang Weigen Song Xueli Cai Guangxian Nan Di Li Alvin Yi-Chou Wang Wentong Ling Chuwei Cai Changming Wen En Wang Liyong Zhang Changchun Jiang Yajie Liu Geng Liao Xiaohui Chen Tianxiao Li Shudong Liu Jinglun Li Yaxuan Sun Na Xu Zong’en Gao Dongsheng Ju Cunfeng Song Jinggang Xuan Feng Zhou Qing Shi Jun Luo Yan Liu Zaiyu Guo Tong Li Hongbo Zheng Linzhi Dai Junfeng Zhao Liqiang Gui Xiaokun Geng Yufeng Tang Congguo Yin Hua Yang |
| author_sort | Lina Zheng |
| collection | DOAJ |
| description | Summary: Background: Endovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with large infarction. Revealing subgroups of patients who would or would not benefit from EVT will further inform patient selection for EVT. Methods: This post-hoc analysis of the ANGEL-ASPECT trial, a randomised controlled trial of 456 adult patients with acute anterior-circulation LVO and large infarction, defined by ASPECTS 3–5 or infarct core volume 70–100 mL, enrolled from 46 centres across China, between October 2, 2020 and May 18, 2022. Patients were randomly assigned (1:1) to receiving EVT and medical management or medical management alone. One patient withdrew consent, 455 patients were included in this post-hoc analysis and categorised into 4 subgroups by lower or higher NIHSS (< or ≥16) and smaller or larger infarct core (< or ≥70 mL). Those with lower NIHSS & smaller core, and higher NIHSS & larger core were considered clinical-radiological matched subgroups; otherwise clinical-radiological mismatched subgroups. Primary outcome was 90-day modified Rankin Scale (mRS). ANGEL-ASPECT is registered with ClinicalTrials.gov, NCT04551664. Findings: Overall, 139 (30.5%) patients had lower NIHSS & smaller core, 106 (23.3%) higher NIHSS & larger core, 130 (28.6%) higher NIHSS & smaller core, and 80 (17.6%) lower NIHSS & larger core. There was significant ordinal shift in the 90-day mRS toward a better outcome with EVT in clinical-radiological matched subgroups: lower NIHSS & smaller core (generalised OR, 1.76; 95% CI, 1.18–2.62; p = 0.01) and higher NIHSS & larger core (1.64; 1.06–2.54; 0.01); but not in the two clinical-radiological mismatched subgroups. Interpretation: Our findings suggested that in patients with anterior-circulation LVO and large infarction, EVT was associated with improved 90-day functional outcomes in those with matched clinical and radiological severities, but not in those with mismatched clinical and radiological severities. Simultaneous consideration of stroke severity and infarct core volume may inform patient selection for EVT. Funding: Unrestricted grants from industry [Covidien Healthcare International Trading (Shanghai), Johnson & Johnson MedTech, Genesis MedTech (Shanghai), and Shanghai HeartCare Medical Technology]. |
| first_indexed | 2024-04-24T10:04:15Z |
| format | Article |
| id | doaj.art-7a2c1c863026444084c22ac02086c170 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-04-24T10:04:15Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-7a2c1c863026444084c22ac02086c1702024-04-13T04:21:40ZengElsevierEClinicalMedicine2589-53702024-06-0172102595Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in contextLina Zheng0Ximing Nie1Mengxing Wang2Xin Liu3Wanying Duan4Zhe Zhang5Jingyi Liu6Yufei Wei7Miao Wen8Zhonghua Yang9Thomas W. Leung10Gaoting Ma11Xiaochuan Huo12Yuesong Pan13Thanh N. Nguyen14Xinyi Leng15Zhongrong Miao16Liping Liu17Yongjun WangYilong WangLiping LiuDavid S. LiebeskindZhongrong MiaoZeguang RenVitor Mendes PereiraXunming JiQiang DongAnding XuXinfeng LiuQingwu YangJing Jing (Chair)Zhe ZhangYingkui ZhangWei WuDapeng SunZhongqi QiShuo LiZhenqiang LiuZequan YuJingyu ZhangFangguang ChenKangyue LiKai ZhangMingkai HuJianmin Liu (Chair)Chen YaoKangning ChenKun Fang (Chair)Bo SongYi DongZhongrong MiaoXiaochuan HuoGaoting MaGuangxiong YuanHongxing HanWenhuo ChenMing WeiJiangang ZhangZhiming ZhouXiaoxi YaoGuoqing WangWeigen SongXueli CaiGuangxian NanDi LiYizhou WangWentong LingChuwei CaiChangming WenEn WangLiyong ZhangChangchun JiangYajie LiuGeng LiaoXiaohui ChenTianxiao LiShudong LiuJinglun LiYaxuan SunNa XuZong’en GaoDongsheng JuCunfeng SongJinggang XuanFeng ZhouQing ShiJun LuoYan LiuZaiyu GuoTong LiHongbo ZhengLinzhi DaiJunfeng ZhaoLiqiang GuiXiaokun GengYufeng TangCongguo YinHua YangXiaochuan HuoGaoting MaRuiyang AnYuying SunYanan WuChunlai YuShuangcheng ZhengYuesong PanAoming JinXianglong XiangMengxing WangHongyi YanYuanling HeChunyang LiWeixia KongYuhuan ChenChenhao GuoFengjie JiPengshan JiLei LiuXinghua LuGuangkuo LuoNanjing WangYu ZhangBo LiuJian YangJingjing DengJuan WangWanru WangHang YuLe CuiWenwen LiuZiyong WangXia ZhaoZhou ZhouZhongrong MiaoGuangxiong YuanHongxing HanWenhuo ChenMing WeiJiangang ZhangZhiming ZhouXiaoxi YaoGuoqing WangWeigen SongXueli CaiGuangxian NanDi LiAlvin Yi-Chou WangWentong LingChuwei CaiChangming WenEn WangLiyong ZhangChangchun JiangYajie LiuGeng LiaoXiaohui ChenTianxiao LiShudong LiuJinglun LiYaxuan SunNa XuZong’en GaoDongsheng JuCunfeng SongJinggang XuanFeng ZhouQing ShiJun LuoYan LiuZaiyu GuoTong LiHongbo ZhengLinzhi DaiJunfeng ZhaoLiqiang GuiXiaokun GengYufeng TangCongguo YinHua YangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, ChinaChina National Clinical Research Centre for Neurological Diseases, Beijing, China; Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCerebrovascular Disease Department, Neurological Disease Centre, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Centre for Neurological Diseases, Beijing, China; Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Radiology Boston Medical Centre, MA, USADepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China; Corresponding author. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR 999077, China.Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, China; Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Corresponding author. Interventional Neuroradiology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 West Road, South 4th Ring, Fengtai District, Beijing 100070, China.Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Centre for Neurological Diseases, Beijing, China; Corresponding author. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 West Road, South 4th Ring, Fengtai District, Beijing 100070, China.Summary: Background: Endovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with large infarction. Revealing subgroups of patients who would or would not benefit from EVT will further inform patient selection for EVT. Methods: This post-hoc analysis of the ANGEL-ASPECT trial, a randomised controlled trial of 456 adult patients with acute anterior-circulation LVO and large infarction, defined by ASPECTS 3–5 or infarct core volume 70–100 mL, enrolled from 46 centres across China, between October 2, 2020 and May 18, 2022. Patients were randomly assigned (1:1) to receiving EVT and medical management or medical management alone. One patient withdrew consent, 455 patients were included in this post-hoc analysis and categorised into 4 subgroups by lower or higher NIHSS (< or ≥16) and smaller or larger infarct core (< or ≥70 mL). Those with lower NIHSS & smaller core, and higher NIHSS & larger core were considered clinical-radiological matched subgroups; otherwise clinical-radiological mismatched subgroups. Primary outcome was 90-day modified Rankin Scale (mRS). ANGEL-ASPECT is registered with ClinicalTrials.gov, NCT04551664. Findings: Overall, 139 (30.5%) patients had lower NIHSS & smaller core, 106 (23.3%) higher NIHSS & larger core, 130 (28.6%) higher NIHSS & smaller core, and 80 (17.6%) lower NIHSS & larger core. There was significant ordinal shift in the 90-day mRS toward a better outcome with EVT in clinical-radiological matched subgroups: lower NIHSS & smaller core (generalised OR, 1.76; 95% CI, 1.18–2.62; p = 0.01) and higher NIHSS & larger core (1.64; 1.06–2.54; 0.01); but not in the two clinical-radiological mismatched subgroups. Interpretation: Our findings suggested that in patients with anterior-circulation LVO and large infarction, EVT was associated with improved 90-day functional outcomes in those with matched clinical and radiological severities, but not in those with mismatched clinical and radiological severities. Simultaneous consideration of stroke severity and infarct core volume may inform patient selection for EVT. Funding: Unrestricted grants from industry [Covidien Healthcare International Trading (Shanghai), Johnson & Johnson MedTech, Genesis MedTech (Shanghai), and Shanghai HeartCare Medical Technology].http://www.sciencedirect.com/science/article/pii/S2589537024001743Endovascular therapyAcute ischaemic strokeLarge vessel occlusionLarge infarct corePost hoc analysis |
| spellingShingle | Lina Zheng Ximing Nie Mengxing Wang Xin Liu Wanying Duan Zhe Zhang Jingyi Liu Yufei Wei Miao Wen Zhonghua Yang Thomas W. Leung Gaoting Ma Xiaochuan Huo Yuesong Pan Thanh N. Nguyen Xinyi Leng Zhongrong Miao Liping Liu Yongjun Wang Yilong Wang Liping Liu David S. Liebeskind Zhongrong Miao Zeguang Ren Vitor Mendes Pereira Xunming Ji Qiang Dong Anding Xu Xinfeng Liu Qingwu Yang Jing Jing (Chair) Zhe Zhang Yingkui Zhang Wei Wu Dapeng Sun Zhongqi Qi Shuo Li Zhenqiang Liu Zequan Yu Jingyu Zhang Fangguang Chen Kangyue Li Kai Zhang Mingkai Hu Jianmin Liu (Chair) Chen Yao Kangning Chen Kun Fang (Chair) Bo Song Yi Dong Zhongrong Miao Xiaochuan Huo Gaoting Ma Guangxiong Yuan Hongxing Han Wenhuo Chen Ming Wei Jiangang Zhang Zhiming Zhou Xiaoxi Yao Guoqing Wang Weigen Song Xueli Cai Guangxian Nan Di Li Yizhou Wang Wentong Ling Chuwei Cai Changming Wen En Wang Liyong Zhang Changchun Jiang Yajie Liu Geng Liao Xiaohui Chen Tianxiao Li Shudong Liu Jinglun Li Yaxuan Sun Na Xu Zong’en Gao Dongsheng Ju Cunfeng Song Jinggang Xuan Feng Zhou Qing Shi Jun Luo Yan Liu Zaiyu Guo Tong Li Hongbo Zheng Linzhi Dai Junfeng Zhao Liqiang Gui Xiaokun Geng Yufeng Tang Congguo Yin Hua Yang Xiaochuan Huo Gaoting Ma Ruiyang An Yuying Sun Yanan Wu Chunlai Yu Shuangcheng Zheng Yuesong Pan Aoming Jin Xianglong Xiang Mengxing Wang Hongyi Yan Yuanling He Chunyang Li Weixia Kong Yuhuan Chen Chenhao Guo Fengjie Ji Pengshan Ji Lei Liu Xinghua Lu Guangkuo Luo Nanjing Wang Yu Zhang Bo Liu Jian Yang Jingjing Deng Juan Wang Wanru Wang Hang Yu Le Cui Wenwen Liu Ziyong Wang Xia Zhao Zhou Zhou Zhongrong Miao Guangxiong Yuan Hongxing Han Wenhuo Chen Ming Wei Jiangang Zhang Zhiming Zhou Xiaoxi Yao Guoqing Wang Weigen Song Xueli Cai Guangxian Nan Di Li Alvin Yi-Chou Wang Wentong Ling Chuwei Cai Changming Wen En Wang Liyong Zhang Changchun Jiang Yajie Liu Geng Liao Xiaohui Chen Tianxiao Li Shudong Liu Jinglun Li Yaxuan Sun Na Xu Zong’en Gao Dongsheng Ju Cunfeng Song Jinggang Xuan Feng Zhou Qing Shi Jun Luo Yan Liu Zaiyu Guo Tong Li Hongbo Zheng Linzhi Dai Junfeng Zhao Liqiang Gui Xiaokun Geng Yufeng Tang Congguo Yin Hua Yang Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context EClinicalMedicine Endovascular therapy Acute ischaemic stroke Large vessel occlusion Large infarct core Post hoc analysis |
| title | Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context |
| title_full | Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context |
| title_fullStr | Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context |
| title_full_unstemmed | Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context |
| title_short | Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context |
| title_sort | endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical radiological severities a post hoc analysis of the angel aspect trialresearch in context |
| topic | Endovascular therapy Acute ischaemic stroke Large vessel occlusion Large infarct core Post hoc analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2589537024001743 |
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endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT yuzhang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT boliu endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT jianyang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT jingjingdeng endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT juanwang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT wanruwang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT hangyu endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT lecui endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT wenwenliu endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT ziyongwang 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endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT wenhuochen endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT mingwei endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT jiangangzhang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT zhimingzhou endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT xiaoxiyao endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT guoqingwang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT weigensong endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT xuelicai endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT guangxiannan endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT dili endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT alvinyichouwang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT wentongling endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT chuweicai endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT changmingwen endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT enwang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT liyongzhang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT changchunjiang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT yajieliu endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT gengliao endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT xiaohuichen endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT tianxiaoli endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT shudongliu endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT jinglunli endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT yaxuansun endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT naxu endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT zongengao endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT dongshengju endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT cunfengsong endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT jinggangxuan endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT fengzhou endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT qingshi endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT junluo endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT yanliu endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT zaiyuguo endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT tongli endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT hongbozheng endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT linzhidai endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT junfengzhao endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT liqianggui endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT xiaokungeng endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT yufengtang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT congguoyin endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext AT huayang endovasculartherapyinacuteischaemicstrokewithlargeinfarctionwithmatchedormismatchedclinicalradiologicalseveritiesaposthocanalysisoftheangelaspecttrialresearchincontext |