Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome
Background: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol<sup>®</sup>, Tilman SA, Baillonville, Belg...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/9/872 |
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| author | Michel P. Hermans Philippe Lempereur Jean-Paul Salembier Nathalie Maes Adelin Albert Olivia Jansen Joël Pincemail |
| author_facet | Michel P. Hermans Philippe Lempereur Jean-Paul Salembier Nathalie Maes Adelin Albert Olivia Jansen Joël Pincemail |
| author_sort | Michel P. Hermans |
| collection | DOAJ |
| description | Background: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol<sup>®</sup>, Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Methods: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol<sup>®</sup>, two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined. Results: Significant reductions (<i>p</i> < 0.0001) in SBP/DBP (13 ± 10/7.1 ± 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP/DPB were independent of age and gender but greater for elevated baseline SBP/DBP. Tensiofytol<sup>®</sup> supplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients. Conclusions: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers. |
| first_indexed | 2024-03-10T16:18:39Z |
| format | Article |
| id | doaj.art-7a2c2433b6624f75bf6e0ba7a3f1a885 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T16:18:39Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-7a2c2433b6624f75bf6e0ba7a3f1a8852023-11-20T13:50:36ZengMDPI AGAntioxidants2076-39212020-09-019987210.3390/antiox9090872Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic SyndromeMichel P. Hermans0Philippe Lempereur1Jean-Paul Salembier2Nathalie Maes3Adelin Albert4Olivia Jansen5Joël Pincemail6Service d’Endocrinologie et de Nutrition and Pôle Endocrinologie, Diabète et Nutrition (EDIN), Institut de Recherche expérimentale et clinique, UCLouvain, 1200 Brussels, BelgiumService de Cardiologie, Centre Hospitalier Bois de l’Abbaye, 4100 Seraing, BelgiumService de Cardiologie, CHU UCL Namur - site Sainte-Elisabeth, 5000 Namur, BelgiumBiostatistics and Medico-economic Information Department, University Hospital of Liège, 4000 Liège, BelgiumBiostatistics and Medico-economic Information Department, University Hospital of Liège, 4000 Liège, BelgiumLaboratoire de Pharmacognosie, Centre Interdisciplinaire de Recherche sur le Médicament (CIRM), Université de Liège, 4000 Liège, BelgiumDepartment of Cardiovascular Surgery, CREDEC and Platform Nutrition Antioxydante et Santé, CHU and University of Liège, Sart Tilman, 4000 Liège, BelgiumBackground: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol<sup>®</sup>, Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Methods: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol<sup>®</sup>, two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined. Results: Significant reductions (<i>p</i> < 0.0001) in SBP/DBP (13 ± 10/7.1 ± 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP/DPB were independent of age and gender but greater for elevated baseline SBP/DBP. Tensiofytol<sup>®</sup> supplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients. Conclusions: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.https://www.mdpi.com/2076-3921/9/9/872<i>Olea europea</i> L.olive extractsoleuropeinhydroxytyrosolhypertensionmetabolic syndrome |
| spellingShingle | Michel P. Hermans Philippe Lempereur Jean-Paul Salembier Nathalie Maes Adelin Albert Olivia Jansen Joël Pincemail Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome Antioxidants <i>Olea europea</i> L. olive extracts oleuropein hydroxytyrosol hypertension metabolic syndrome |
| title | Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome |
| title_full | Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome |
| title_fullStr | Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome |
| title_full_unstemmed | Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome |
| title_short | Supplementation Effect of a Combination of Olive (<i>Olea europea</i> L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome |
| title_sort | supplementation effect of a combination of olive i olea europea i l leaf and fruit extracts in the clinical management of hypertension and metabolic syndrome |
| topic | <i>Olea europea</i> L. olive extracts oleuropein hydroxytyrosol hypertension metabolic syndrome |
| url | https://www.mdpi.com/2076-3921/9/9/872 |
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