Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation

Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation

Glutamine is critical for tumor progression, and restriction of its availability is emerging as a potential therapeutic strategy. The metabolic plasticity of tumor cells helps them adapting to glutamine restriction. However, the role of cholesterol metabolism in this process is relatively unexplored...

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Bibliographic Details
Main Authors: Youzi Kong, Mengting Wu, Xiaoyu Wan, Min Sun, Yankun Zhang, Zhuanchang Wu, Chunyang Li, Xiaohong Liang, Lifen Gao, Chunhong Ma, Xuetian Yue
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Redox Biology
Subjects:
Glutamine metabolism
Cholesterol metabolism
SREBF2
Redox balance
mTORC1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001337

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