Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat.
BACKGROUND:Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role. This study aimed to determine whether the expression of end...
Main Authors: | Gry Freja Skovsted, Lars Schack Kruse, Lukas Adrian Berchtold, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5360328?pdf=render |
Similar Items
-
Cryo-EM structure of the endothelin-1-ETB-Gi complex
by: Fumiya K Sano, et al.
Published: (2023-04-01) -
Early MEK1/2 inhibition after global cerebral ischemia in rats reduces brain damage and improves outcome by preventing delayed vasoconstrictor receptor upregulation.
by: Sara Ellinor Johansson, et al.
Published: (2014-01-01) -
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
by: Xu, S, et al.
Published: (2004) -
The MEK Inhibitor Trametinib Improves Outcomes following Subarachnoid Haemorrhage in Female Rats
by: Jesper Peter Bömers, et al.
Published: (2022-11-01) -
Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway
by: Nilsson Ola, et al.
Published: (2011-01-01)