Executive Function and Working Memory Deficits in Females with Fragile X Premutation
The Fragile X premutation is a genetic instability of the <i>FMR1</i> gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were found to have difficulties in e...
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MDPI AG
2023-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/813 |
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| author | Osnat Segal Tamar Kowal Yonit Banet-Levi Lidia V. Gabis |
| author_facet | Osnat Segal Tamar Kowal Yonit Banet-Levi Lidia V. Gabis |
| author_sort | Osnat Segal |
| collection | DOAJ |
| description | The Fragile X premutation is a genetic instability of the <i>FMR1</i> gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were found to have difficulties in executive functions and working memory, little data have been collected on females. This study is among the first to address executive functions and phonological memory in females with the Fragile X premutation. Twenty-three female carriers aged 20–55 years and twelve non carrier females matched in age and levels of education (in years) participated in this study. Executive functions and phonological memory were assessed using the self-report questionnaire The Behavior Rating Inventory of Executive Function (BRIEF) and behavioral measures (nonword repetitions, forward and backward digit span). Females who were carriers of the premutation of the FMR1 gene reported less efficient executive functions in the BRIEF questionnaire compared to the control group. In addition, a relationship was found between the number of repetitions on the CGG sequence of nucleotides, nonword repetitions, and forward digit span. The findings suggest that the premutation of Fragile X in females affects their performance of executive functions and may have impact on everyday functioning. |
| first_indexed | 2024-03-11T06:17:19Z |
| format | Article |
| id | doaj.art-7a2de4c3b0044882a33588aae96fa0f5 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:19Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-7a2de4c3b0044882a33588aae96fa0f52023-11-17T12:12:43ZengMDPI AGLife2075-17292023-03-0113381310.3390/life13030813Executive Function and Working Memory Deficits in Females with Fragile X PremutationOsnat Segal0Tamar Kowal1Yonit Banet-Levi2Lidia V. Gabis3Department of Communication Disorders, The Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, IsraelDepartment of Communication Disorders, The Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, IsraelMaccabi Healthcare, Tel Aviv 6200522, IsraelKeshet Autism Center Maccabi Wolfson, Holon 5822012, IsraelThe Fragile X premutation is a genetic instability of the <i>FMR1</i> gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were found to have difficulties in executive functions and working memory, little data have been collected on females. This study is among the first to address executive functions and phonological memory in females with the Fragile X premutation. Twenty-three female carriers aged 20–55 years and twelve non carrier females matched in age and levels of education (in years) participated in this study. Executive functions and phonological memory were assessed using the self-report questionnaire The Behavior Rating Inventory of Executive Function (BRIEF) and behavioral measures (nonword repetitions, forward and backward digit span). Females who were carriers of the premutation of the FMR1 gene reported less efficient executive functions in the BRIEF questionnaire compared to the control group. In addition, a relationship was found between the number of repetitions on the CGG sequence of nucleotides, nonword repetitions, and forward digit span. The findings suggest that the premutation of Fragile X in females affects their performance of executive functions and may have impact on everyday functioning.https://www.mdpi.com/2075-1729/13/3/813fragile X premutationfemalesexecutive functionsphonological working memoryclinical geneticsadults |
| spellingShingle | Osnat Segal Tamar Kowal Yonit Banet-Levi Lidia V. Gabis Executive Function and Working Memory Deficits in Females with Fragile X Premutation Life fragile X premutation females executive functions phonological working memory clinical genetics adults |
| title | Executive Function and Working Memory Deficits in Females with Fragile X Premutation |
| title_full | Executive Function and Working Memory Deficits in Females with Fragile X Premutation |
| title_fullStr | Executive Function and Working Memory Deficits in Females with Fragile X Premutation |
| title_full_unstemmed | Executive Function and Working Memory Deficits in Females with Fragile X Premutation |
| title_short | Executive Function and Working Memory Deficits in Females with Fragile X Premutation |
| title_sort | executive function and working memory deficits in females with fragile x premutation |
| topic | fragile X premutation females executive functions phonological working memory clinical genetics adults |
| url | https://www.mdpi.com/2075-1729/13/3/813 |
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