Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervationResearch in context

Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervationResearch in context

Background: Patient-derived xenograft (PDX) models have significantly enhanced cancer research, and often serve as a robust model. However, enhanced growth rate and altered pathological phenotype with serial passages have repeatedly been shown in adenoid cystic carcinoma (ACC) PDX tumors, which is a...

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Bibliographic Details
Main Authors:	Ashley Cornett, Harleen K. Athwal, Emily Hill, George Murphy, III, Kenji Yeoh, Christopher A. Moskaluk, Robert L. Witt, Nisha J. D'Silva, Seema Agarwal, Isabelle M.A. Lombaert
Format:	Article
Language:	English
Published:	Elsevier 2019-03-01
Series:	EBioMedicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396419300829

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