Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study
Abstract Introduction This article aims to evaluate the prognostic value of ferritin in patients with severe fever with thrombocytopenia syndrome (SFTS). Methods Patients with SFTS diagnosed at the Infection Department of Wuhan Union Medical College Hospital from July 2018 to November 2021 were incl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-03-01
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| Series: | Infectious Diseases and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40121-023-00784-3 |
| _version_ | 1827983195742666752 |
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| author | Jiao Xie Mengzhao Su Yiping Dang Lei Zhao |
| author_facet | Jiao Xie Mengzhao Su Yiping Dang Lei Zhao |
| author_sort | Jiao Xie |
| collection | DOAJ |
| description | Abstract Introduction This article aims to evaluate the prognostic value of ferritin in patients with severe fever with thrombocytopenia syndrome (SFTS). Methods Patients with SFTS diagnosed at the Infection Department of Wuhan Union Medical College Hospital from July 2018 to November 2021 were included. The best cutoff value was determined by receiver-operating characteristic (ROC) curve. The survival curve was analyzed by Kaplan-Meier method and compared among different serum ferritin subgroups by log-rank test. Cox regression model was used to evaluate the effect of prognosis on overall survival (OS). Results A total of 229 patients with febrile thrombocytopenia syndrome were enrolled. There were 42 fatal cases, with a fatality rate of 18.3%. The best critical value of serum ferritin was 16.775 mg/l. With increasing serum ferritin level, the cumulative mortality increased significantly (log-rank, P < 0.001). Cox univariate regression analysis and adjusted confounding factors such as age, viral load, liver and kidney function and blood coagulation function showed that, compared with the low ferritin group, the high ferritin group demonstrated poorer OS. Conclusions The serum ferritin level before treatment can be considered a valuable index for predicting the prognosis of patients with SFTS. |
| first_indexed | 2024-04-09T22:44:56Z |
| format | Article |
| id | doaj.art-7a2fed77360845a48c560c24625a2d16 |
| institution | Directory Open Access Journal |
| issn | 2193-8229 2193-6382 |
| language | English |
| last_indexed | 2024-04-09T22:44:56Z |
| publishDate | 2023-03-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj.art-7a2fed77360845a48c560c24625a2d162023-03-22T11:56:24ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822023-03-0112397998810.1007/s40121-023-00784-3Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort StudyJiao Xie0Mengzhao Su1Yiping Dang2Lei Zhao3Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Introduction This article aims to evaluate the prognostic value of ferritin in patients with severe fever with thrombocytopenia syndrome (SFTS). Methods Patients with SFTS diagnosed at the Infection Department of Wuhan Union Medical College Hospital from July 2018 to November 2021 were included. The best cutoff value was determined by receiver-operating characteristic (ROC) curve. The survival curve was analyzed by Kaplan-Meier method and compared among different serum ferritin subgroups by log-rank test. Cox regression model was used to evaluate the effect of prognosis on overall survival (OS). Results A total of 229 patients with febrile thrombocytopenia syndrome were enrolled. There were 42 fatal cases, with a fatality rate of 18.3%. The best critical value of serum ferritin was 16.775 mg/l. With increasing serum ferritin level, the cumulative mortality increased significantly (log-rank, P < 0.001). Cox univariate regression analysis and adjusted confounding factors such as age, viral load, liver and kidney function and blood coagulation function showed that, compared with the low ferritin group, the high ferritin group demonstrated poorer OS. Conclusions The serum ferritin level before treatment can be considered a valuable index for predicting the prognosis of patients with SFTS.https://doi.org/10.1007/s40121-023-00784-3Severe fever with thrombocytopenia syndromeFerritinPrognosticAdverse outcomeRisk factors |
| spellingShingle | Jiao Xie Mengzhao Su Yiping Dang Lei Zhao Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study Infectious Diseases and Therapy Severe fever with thrombocytopenia syndrome Ferritin Prognostic Adverse outcome Risk factors |
| title | Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study |
| title_full | Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study |
| title_fullStr | Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study |
| title_full_unstemmed | Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study |
| title_short | Prognostic Value of Serum Ferritin for Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study |
| title_sort | prognostic value of serum ferritin for patients with severe fever with thrombocytopenia syndrome a single center retrospective cohort study |
| topic | Severe fever with thrombocytopenia syndrome Ferritin Prognostic Adverse outcome Risk factors |
| url | https://doi.org/10.1007/s40121-023-00784-3 |
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