Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis

Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis

Abstract The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic esophagitis (EoE). We show that esophageal epithelial cells and macrophage-derived NLRP3 regulated IL-18 initiate the disease and induced IL-5 facilitat...

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Main Authors: Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Sandeep Kumar, Hemanth Kumar Kandikattu, Lokanatha Oruganti, Chandra Sekhar Kathera, Anil Mishra
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05130-4

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