Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment
Cancer is a worldwide problem that threatens human health. Radiotherapy plays an important role in a variety of cancer treatment methods. The administration of radiotherapy can alter the differentiation pathways and functions of T cells, which in turn improves the immune response of T cells. Radioth...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-06-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1840254 |
| _version_ | 1827809534839619584 |
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| author | Chen Chen Yanlong Liu Binbin Cui |
| author_facet | Chen Chen Yanlong Liu Binbin Cui |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | Cancer is a worldwide problem that threatens human health. Radiotherapy plays an important role in a variety of cancer treatment methods. The administration of radiotherapy can alter the differentiation pathways and functions of T cells, which in turn improves the immune response of T cells. Radiotherapy can also induce up-regulation of PD-L1 expression, which means that it has great potential for enhancing the therapeutic effect of anti-PD-1/PD-L1 inhibitors and reducing the risk of drug resistance toward them. At present, the combination of radiotherapy and anti-PD-1/PD-L1 inhibitors has shown significant therapeutic effects in clinical tumor research. This review focuses on the mechanism of radiotherapy on T cells reported in recent years, as well as related research progress in the application of PD-1/PD-L1 blockers. It will provide a theoretical basis for the rational clinical application of radiotherapy combined with PD-1/PD-L1 inhibitors. |
| first_indexed | 2024-03-11T22:41:54Z |
| format | Article |
| id | doaj.art-7a30a80a0cbd42b6b5a31413bcb6978d |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:41:54Z |
| publishDate | 2021-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-7a30a80a0cbd42b6b5a31413bcb6978d2023-09-22T08:51:52ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-06-011761555156710.1080/21645515.2020.18402541840254Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironmentChen Chen0Yanlong Liu1Binbin Cui2The Tumor Hospital of Harbin Medical UniversityThe Tumor Hospital of Harbin Medical UniversityThe Tumor Hospital of Harbin Medical UniversityCancer is a worldwide problem that threatens human health. Radiotherapy plays an important role in a variety of cancer treatment methods. The administration of radiotherapy can alter the differentiation pathways and functions of T cells, which in turn improves the immune response of T cells. Radiotherapy can also induce up-regulation of PD-L1 expression, which means that it has great potential for enhancing the therapeutic effect of anti-PD-1/PD-L1 inhibitors and reducing the risk of drug resistance toward them. At present, the combination of radiotherapy and anti-PD-1/PD-L1 inhibitors has shown significant therapeutic effects in clinical tumor research. This review focuses on the mechanism of radiotherapy on T cells reported in recent years, as well as related research progress in the application of PD-1/PD-L1 blockers. It will provide a theoretical basis for the rational clinical application of radiotherapy combined with PD-1/PD-L1 inhibitors.http://dx.doi.org/10.1080/21645515.2020.1840254radiotherapyt cellcd4-cd8pd-1/pd-l1immune resistance |
| spellingShingle | Chen Chen Yanlong Liu Binbin Cui Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment Human Vaccines & Immunotherapeutics radiotherapy t cell cd4-cd8 pd-1/pd-l1 immune resistance |
| title | Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment |
| title_full | Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment |
| title_fullStr | Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment |
| title_full_unstemmed | Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment |
| title_short | Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment |
| title_sort | effect of radiotherapy on t cell and pd 1 pd l1 blocking therapy in tumor microenvironment |
| topic | radiotherapy t cell cd4-cd8 pd-1/pd-l1 immune resistance |
| url | http://dx.doi.org/10.1080/21645515.2020.1840254 |
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