Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review
Due to development of bacterial resistance to the conventional antibiotics, the treatment of bacterial infections has become a major issue of concern. The unprescribed and uncontrolled use of antibiotics has lead to the rapid development of antibiotic resistance in bacterial strains. Therefore, the...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-03-01
|
| Series: | Biotechnology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X19305934 |
| _version_ | 1818537415455801344 |
|---|---|
| author | Anirudh Singh Pavan Kumar Gautam Arushi Verma Vishal Singh Pingali M. Shivapriya Saurabh Shivalkar Amaresh Kumar Sahoo Sintu Kumar Samanta |
| author_facet | Anirudh Singh Pavan Kumar Gautam Arushi Verma Vishal Singh Pingali M. Shivapriya Saurabh Shivalkar Amaresh Kumar Sahoo Sintu Kumar Samanta |
| author_sort | Anirudh Singh |
| collection | DOAJ |
| description | Due to development of bacterial resistance to the conventional antibiotics, the treatment of bacterial infections has become a major issue of concern. The unprescribed and uncontrolled use of antibiotics has lead to the rapid development of antibiotic resistance in bacterial strains. Therefore, the development of novel and potent bactericidal agents is of great clinical importance. Interestingly, metallic nanoparticles (NPs) have been proven to be promising alternative to antibiotics. NPs interact with the important cellular organelles and biomolecules like DNA, enzymes, ribosomes, and lysosomes that can affect cell membrane permeability, oxidative stress, gene expression, protein activation, and enzyme activation. Since, NPs target multiple biomolecules concurrently; it becomes very difficult for bacteria to develop resistance against them. Currently, there are different physical and chemical methods utilized for NPs synthesis. However, most of these processes are costly and potentially hazardous for the living organisms and environment. Therefore, there is a need to develop an eco-friendly and cost-effective method of synthesis. Recently, the ‘green synthesis’ approaches are gaining a lot of attention. It is demonstrated that living organisms like bacteria, yeast, fungi, and plant cells can reduce inorganic metal ions into metal NPs by their cellular metabolites. Both the yield and stability of biogenic NPs are quite satisfactory. In the current article, we have addressed the green synthesis of various metal NPs reported till date and highlighted their different modes and mechanisms of antibacterial properties. It is highly anticipated that biogenic metallic NPs could be viable and economical alternatives for treating drug resistant bacterial infections in near future. Keywords: Metallic nanoparticles, Green synthesis, Antibacterial property, Antibiotics resistance |
| first_indexed | 2024-12-11T18:50:30Z |
| format | Article |
| id | doaj.art-7a333d6caaf14aaf8a0053c1af7935bf |
| institution | Directory Open Access Journal |
| issn | 2215-017X |
| language | English |
| last_indexed | 2024-12-11T18:50:30Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj.art-7a333d6caaf14aaf8a0053c1af7935bf2022-12-22T00:54:19ZengElsevierBiotechnology Reports2215-017X2020-03-0125Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A reviewAnirudh Singh0Pavan Kumar Gautam1Arushi Verma2Vishal Singh3Pingali M. Shivapriya4Saurabh Shivalkar5Amaresh Kumar Sahoo6Sintu Kumar Samanta7Department of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaDepartment of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaDepartment of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaDepartment of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaDepartment of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaDepartment of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaCorresponding author.; Department of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaCorresponding author.; Department of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, IndiaDue to development of bacterial resistance to the conventional antibiotics, the treatment of bacterial infections has become a major issue of concern. The unprescribed and uncontrolled use of antibiotics has lead to the rapid development of antibiotic resistance in bacterial strains. Therefore, the development of novel and potent bactericidal agents is of great clinical importance. Interestingly, metallic nanoparticles (NPs) have been proven to be promising alternative to antibiotics. NPs interact with the important cellular organelles and biomolecules like DNA, enzymes, ribosomes, and lysosomes that can affect cell membrane permeability, oxidative stress, gene expression, protein activation, and enzyme activation. Since, NPs target multiple biomolecules concurrently; it becomes very difficult for bacteria to develop resistance against them. Currently, there are different physical and chemical methods utilized for NPs synthesis. However, most of these processes are costly and potentially hazardous for the living organisms and environment. Therefore, there is a need to develop an eco-friendly and cost-effective method of synthesis. Recently, the ‘green synthesis’ approaches are gaining a lot of attention. It is demonstrated that living organisms like bacteria, yeast, fungi, and plant cells can reduce inorganic metal ions into metal NPs by their cellular metabolites. Both the yield and stability of biogenic NPs are quite satisfactory. In the current article, we have addressed the green synthesis of various metal NPs reported till date and highlighted their different modes and mechanisms of antibacterial properties. It is highly anticipated that biogenic metallic NPs could be viable and economical alternatives for treating drug resistant bacterial infections in near future. Keywords: Metallic nanoparticles, Green synthesis, Antibacterial property, Antibiotics resistancehttp://www.sciencedirect.com/science/article/pii/S2215017X19305934 |
| spellingShingle | Anirudh Singh Pavan Kumar Gautam Arushi Verma Vishal Singh Pingali M. Shivapriya Saurabh Shivalkar Amaresh Kumar Sahoo Sintu Kumar Samanta Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review Biotechnology Reports |
| title | Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review |
| title_full | Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review |
| title_fullStr | Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review |
| title_full_unstemmed | Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review |
| title_short | Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review |
| title_sort | green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections a review |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X19305934 |
| work_keys_str_mv | AT anirudhsingh greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview AT pavankumargautam greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview AT arushiverma greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview AT vishalsingh greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview AT pingalimshivapriya greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview AT saurabhshivalkar greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview AT amareshkumarsahoo greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview AT sintukumarsamanta greensynthesisofmetallicnanoparticlesaseffectivealternativestotreatantibioticsresistantbacterialinfectionsareview |