Serum zinc associated with immunity and inflammatory markers in Covid-19
This study aimed to assess the association between serum zinc level with some inflammatory and immunity factors and the duration of hospitalization and mortality rate in patients diagnosed with Covid-19. In this cross-sectional study, blood samples were taken from polymerase chain reaction (PCR) pos...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-04-01
|
| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2022-0469 |
| _version_ | 1811203011955916800 |
|---|---|
| author | Joulaei Hassan Keshani Parisa Foroozanfar Zohre Zamanian Daniel Hassani Amirhossein Parvizi Fateme Khadem Yasaman Omidifar Navid Davarpanah Mohammad Ali |
| author_facet | Joulaei Hassan Keshani Parisa Foroozanfar Zohre Zamanian Daniel Hassani Amirhossein Parvizi Fateme Khadem Yasaman Omidifar Navid Davarpanah Mohammad Ali |
| author_sort | Joulaei Hassan |
| collection | DOAJ |
| description | This study aimed to assess the association between serum zinc level with some inflammatory and immunity factors and the duration of hospitalization and mortality rate in patients diagnosed with Covid-19. In this cross-sectional study, blood samples were taken from polymerase chain reaction (PCR) positive patients. New patients diagnosed with Covid-19, admitted to different public hospital wards, were considered eligible for entering the study. The study was done on 179 hospitalized patients diagnosed with Covid-19. Fourteen patients died during the hospitalization and the in-hospital mortality rate was 7.8%, with 9.1% (13 patients) of patients with serum zinc level less than 70 mcg/dL and 3.4% (1 patient) of patients with zinc levels more than 70 mcg/dL. Higher levels of zinc were significantly associated with a higher and lower level of interferon-gamma (IFN-γ) (p-value = 0.035) and interleukin (IL)-6 (p-value = 0.004), respectively. The level of serum zinc did not have a significant association with mortality even after adjusting for confounding factors. The relationship between zinc level and the duration of hospitalization was also not significant. In conclusion, serum zinc level had an association with IL-6 and IFN-γ level, but it did not have any significant association with hospital duration or mortality. |
| first_indexed | 2024-04-12T02:47:41Z |
| format | Article |
| id | doaj.art-7a33cfdb1f284d4c8502ef36e852490a |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T02:47:41Z |
| publishDate | 2022-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-7a33cfdb1f284d4c8502ef36e852490a2022-12-22T03:51:06ZengDe GruyterOpen Medicine2391-54632022-04-0117170271110.1515/med-2022-0469Serum zinc associated with immunity and inflammatory markers in Covid-19Joulaei Hassan0Keshani Parisa1Foroozanfar Zohre2Zamanian Daniel3Hassani Amirhossein4Parvizi Fateme5Khadem Yasaman6Omidifar Navid7Davarpanah Mohammad Ali8Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranHIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranHIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranHIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, IranClinical Education Research Center, and Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranHIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranThis study aimed to assess the association between serum zinc level with some inflammatory and immunity factors and the duration of hospitalization and mortality rate in patients diagnosed with Covid-19. In this cross-sectional study, blood samples were taken from polymerase chain reaction (PCR) positive patients. New patients diagnosed with Covid-19, admitted to different public hospital wards, were considered eligible for entering the study. The study was done on 179 hospitalized patients diagnosed with Covid-19. Fourteen patients died during the hospitalization and the in-hospital mortality rate was 7.8%, with 9.1% (13 patients) of patients with serum zinc level less than 70 mcg/dL and 3.4% (1 patient) of patients with zinc levels more than 70 mcg/dL. Higher levels of zinc were significantly associated with a higher and lower level of interferon-gamma (IFN-γ) (p-value = 0.035) and interleukin (IL)-6 (p-value = 0.004), respectively. The level of serum zinc did not have a significant association with mortality even after adjusting for confounding factors. The relationship between zinc level and the duration of hospitalization was also not significant. In conclusion, serum zinc level had an association with IL-6 and IFN-γ level, but it did not have any significant association with hospital duration or mortality.https://doi.org/10.1515/med-2022-0469serum zincinterleukin-6interferon-gammaduration of hospitalizationmortality ratecovid-19 |
| spellingShingle | Joulaei Hassan Keshani Parisa Foroozanfar Zohre Zamanian Daniel Hassani Amirhossein Parvizi Fateme Khadem Yasaman Omidifar Navid Davarpanah Mohammad Ali Serum zinc associated with immunity and inflammatory markers in Covid-19 Open Medicine serum zinc interleukin-6 interferon-gamma duration of hospitalization mortality rate covid-19 |
| title | Serum zinc associated with immunity and inflammatory markers in Covid-19 |
| title_full | Serum zinc associated with immunity and inflammatory markers in Covid-19 |
| title_fullStr | Serum zinc associated with immunity and inflammatory markers in Covid-19 |
| title_full_unstemmed | Serum zinc associated with immunity and inflammatory markers in Covid-19 |
| title_short | Serum zinc associated with immunity and inflammatory markers in Covid-19 |
| title_sort | serum zinc associated with immunity and inflammatory markers in covid 19 |
| topic | serum zinc interleukin-6 interferon-gamma duration of hospitalization mortality rate covid-19 |
| url | https://doi.org/10.1515/med-2022-0469 |
| work_keys_str_mv | AT joulaeihassan serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT keshaniparisa serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT foroozanfarzohre serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT zamaniandaniel serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT hassaniamirhossein serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT parvizifateme serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT khademyasaman serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT omidifarnavid serumzincassociatedwithimmunityandinflammatorymarkersincovid19 AT davarpanahmohammadali serumzincassociatedwithimmunityandinflammatorymarkersincovid19 |