mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

Abstract Pathogenic mitochondrial DNA (mtDNA) mutations often co‐exist with wild‐type molecules (mtDNA heteroplasmy). Phenotypes manifest when the percentage of mutant mtDNA is high (70–90%). Previously, our laboratory showed that mitochondria‐targeted transcription activator‐like effector nucleases...

Full description

Bibliographic Details
Main Authors: Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes
Format: Article
Language:English
Published: Springer Nature 2018-09-01
Series:EMBO Molecular Medicine
Subjects:
heteroplasmy
I‐TevI
mitochondrial DNA
mitoTev‐TALE
monomeric
Online Access:https://doi.org/10.15252/emmm.201708084

Internet

https://doi.org/10.15252/emmm.201708084

Similar Items