Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur
The objective of this study was to determine the proportion of patients with atherosclerotic peripheral vascular disease (PVD) who had elevated lipoprotein(a) [Lp(a)] levels, as well as to determine the latter's significance as a risk factor for PVD in the local population. METHODS: This case-c...
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| Format: | Article |
| Language: | English |
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Elsevier
2008-01-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958408600482 |
| _version_ | 1811208436823621632 |
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| author | N.A. Hakim M.T. Hafizan M.H. Baizurah A.A. Zainal |
| author_facet | N.A. Hakim M.T. Hafizan M.H. Baizurah A.A. Zainal |
| author_sort | N.A. Hakim |
| collection | DOAJ |
| description | The objective of this study was to determine the proportion of patients with atherosclerotic peripheral vascular disease (PVD) who had elevated lipoprotein(a) [Lp(a)] levels, as well as to determine the latter's significance as a risk factor for PVD in the local population.
METHODS: This case-controlled study was conducted between June and October 2004 in the Department of Surgery, Kuala Lumpur Hospital. A total of 100 patients were recruited and divided into control and PVD groups. Patients were defined as having PVD if they were symptomatic, with ankle-brachial systolic index < 0.90, or by radiological evidence. Lp(a) concentrations were determined using immunoturbidometry. Absorbance of reaction precipitate was measured by spectrophotometry to give Lp(a) concentration in grams per litre (g/L). The reference value for normal Lp(a) levels was ≤ 0.36 g/L.
RESULTS: Mean Lp(a) levels for control and PVD groups were 0.29 g/L and 0.56 g/L, and median values were 0.17 g/L and 0.48 g/L, respectively. Elevated Lp(a) levels in the control group was 26% compared to 58% in the PVD group. Analysis with Pearson's χ2 test achieved a significant p value of 0.001. Multivariate analysis showed that elevated Lp(a) levels contributed significantly to the probability of having PVD with an odds ratio of 7.69.
CONCLUSION: Elevated serum Lp(a) has a significant role as a risk factor for atherosclerotic PVD in the local population. |
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| format | Article |
| id | doaj.art-7a3ad576d5e34d9fa52184700e098e55 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-04-12T04:21:18Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-7a3ad576d5e34d9fa52184700e098e552022-12-22T03:48:14ZengElsevierAsian Journal of Surgery1015-95842008-01-01311111510.1016/S1015-9584(08)60048-2Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala LumpurN.A. Hakim0M.T. Hafizan1M.H. Baizurah2A.A. Zainal3Vascular Unit, Department of General Surgery, Hospital Kuala Lumpur, Kuala Lumpur, MalaysiaVascular Unit, Department of General Surgery, Hospital Kuala Lumpur, Kuala Lumpur, MalaysiaVascular Unit, Department of General Surgery, Hospital Kuala Lumpur, Kuala Lumpur, MalaysiaChemical Pathology Unit, Department of Pathology, Hospital Kuala Lumpur, Kuala Lumpur, MalaysiaThe objective of this study was to determine the proportion of patients with atherosclerotic peripheral vascular disease (PVD) who had elevated lipoprotein(a) [Lp(a)] levels, as well as to determine the latter's significance as a risk factor for PVD in the local population. METHODS: This case-controlled study was conducted between June and October 2004 in the Department of Surgery, Kuala Lumpur Hospital. A total of 100 patients were recruited and divided into control and PVD groups. Patients were defined as having PVD if they were symptomatic, with ankle-brachial systolic index < 0.90, or by radiological evidence. Lp(a) concentrations were determined using immunoturbidometry. Absorbance of reaction precipitate was measured by spectrophotometry to give Lp(a) concentration in grams per litre (g/L). The reference value for normal Lp(a) levels was ≤ 0.36 g/L. RESULTS: Mean Lp(a) levels for control and PVD groups were 0.29 g/L and 0.56 g/L, and median values were 0.17 g/L and 0.48 g/L, respectively. Elevated Lp(a) levels in the control group was 26% compared to 58% in the PVD group. Analysis with Pearson's χ2 test achieved a significant p value of 0.001. Multivariate analysis showed that elevated Lp(a) levels contributed significantly to the probability of having PVD with an odds ratio of 7.69. CONCLUSION: Elevated serum Lp(a) has a significant role as a risk factor for atherosclerotic PVD in the local population.http://www.sciencedirect.com/science/article/pii/S1015958408600482atherosclerosislipoprotein(a)peripheral vascular disease |
| spellingShingle | N.A. Hakim M.T. Hafizan M.H. Baizurah A.A. Zainal Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur Asian Journal of Surgery atherosclerosis lipoprotein(a) peripheral vascular disease |
| title | Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur |
| title_full | Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur |
| title_fullStr | Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur |
| title_full_unstemmed | Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur |
| title_short | Serum Lipoprotein(a) Levels in Patients with Atherosclerotic Peripheral Vascular Disease in Hospital Kuala Lumpur |
| title_sort | serum lipoprotein a levels in patients with atherosclerotic peripheral vascular disease in hospital kuala lumpur |
| topic | atherosclerosis lipoprotein(a) peripheral vascular disease |
| url | http://www.sciencedirect.com/science/article/pii/S1015958408600482 |
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