Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response
Summary: The mitochondrial unfolded protein response (UPRmt) is an organellar stress signaling pathway that functions to detect and restore disruption of mitochondrial proteostasis. The UPRmt is involved in a wide range of physiological and disease conditions, including aging, stem cell maintenance,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221010865 |
| _version_ | 1818989980770369536 |
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| author | Yi-Fan Lin Jessica Sam Todd Evans |
| author_facet | Yi-Fan Lin Jessica Sam Todd Evans |
| author_sort | Yi-Fan Lin |
| collection | DOAJ |
| description | Summary: The mitochondrial unfolded protein response (UPRmt) is an organellar stress signaling pathway that functions to detect and restore disruption of mitochondrial proteostasis. The UPRmt is involved in a wide range of physiological and disease conditions, including aging, stem cell maintenance, innate immunity, neurodegeneration, and cancer. Here we report that the UPRmt is integral to zebrafish fin regeneration. Taking advantage of a novel zebrafish UPRmt reporter, we observed that UPRmt activation occurs in regenerating fin tissue shortly after injury. Through chemical and genetic approaches, we discovered that the Sirt1-UPRmt pathway, best known for its role in promoting lifespan extension, is crucial for fin regeneration. The metabolism of NAD+ is an important contributor to Sirt1 activity in this context. We propose that Sirt1 activation induces mitochondrial biogenesis in injured fin tissue, which leads to UPRmt activation and promotes tissue regeneration. |
| first_indexed | 2024-12-20T19:47:06Z |
| format | Article |
| id | doaj.art-7a3b87242f724bb4be9f4e17be69edae |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-20T19:47:06Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-7a3b87242f724bb4be9f4e17be69edae2022-12-21T19:28:24ZengElsevieriScience2589-00422021-10-012410103118Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein responseYi-Fan Lin0Jessica Sam1Todd Evans2Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, LC-708, New York, NY 10065, USA; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 30013, Taiwan; Department of Life Science, National Tsing Hua University, Hsinchu, 30013, Taiwan; Corresponding authorDepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, LC-708, New York, NY 10065, USADepartment of Surgery, Weill Cornell Medicine, 1300 York Avenue, LC-708, New York, NY 10065, USA; Corresponding authorSummary: The mitochondrial unfolded protein response (UPRmt) is an organellar stress signaling pathway that functions to detect and restore disruption of mitochondrial proteostasis. The UPRmt is involved in a wide range of physiological and disease conditions, including aging, stem cell maintenance, innate immunity, neurodegeneration, and cancer. Here we report that the UPRmt is integral to zebrafish fin regeneration. Taking advantage of a novel zebrafish UPRmt reporter, we observed that UPRmt activation occurs in regenerating fin tissue shortly after injury. Through chemical and genetic approaches, we discovered that the Sirt1-UPRmt pathway, best known for its role in promoting lifespan extension, is crucial for fin regeneration. The metabolism of NAD+ is an important contributor to Sirt1 activity in this context. We propose that Sirt1 activation induces mitochondrial biogenesis in injured fin tissue, which leads to UPRmt activation and promotes tissue regeneration.http://www.sciencedirect.com/science/article/pii/S2589004221010865Molecular biologyCell biologyDevelopmental biology |
| spellingShingle | Yi-Fan Lin Jessica Sam Todd Evans Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response iScience Molecular biology Cell biology Developmental biology |
| title | Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response |
| title_full | Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response |
| title_fullStr | Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response |
| title_full_unstemmed | Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response |
| title_short | Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response |
| title_sort | sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response |
| topic | Molecular biology Cell biology Developmental biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221010865 |
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