Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
Purpose To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM). Methods Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498093/?tool=EBI |
| _version_ | 1811305893782880256 |
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| author | Jer-Shyung Huang Huay-Ben Pan Tsung-Lung Yang Bao-Hui Hung Chia-Ling Chiang Meng-Yuan Tsai Chen-Pin Chou Azra Alizad |
| author_facet | Jer-Shyung Huang Huay-Ben Pan Tsung-Lung Yang Bao-Hui Hung Chia-Ling Chiang Meng-Yuan Tsai Chen-Pin Chou Azra Alizad |
| author_sort | Jer-Shyung Huang |
| collection | DOAJ |
| description | Purpose To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM). Methods Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at 2, 3, 4, 7, and 10 min after injection of contrast agent. Three readers visually and semi-quantitatively analyzed the enhancement of suspicious lesions. The kinetic pattern of each lesion was classified as persistent, plateau, or washout over two time intervals, 2–4 min and 2–10 min, by comparing the signal intensity at the first time interval with that at the second. Results There were 73 malignant and 75 benign lesions in 148 patients (mean age: 52 years). Benign and malignant breast lesions showed the highest signal intensity at 3 min and 2 min, respectively. Average areas under receiver operating characteristic (ROC) curve for diagnostic accuracy based on lesion enhancement at different time points were 0.73 at 2 min, 0.72 at 3 min, 0.69 at 4 min, 0.67 at 7 min, and 0.64 at 10 min. Diagnostic performance was significantly better at 2, 3, and 4 min than at 7 and 10 min (all p < 0.05). A washout kinetic pattern was significantly associated with malignant lesions at 2–4 min and 2–10 min frames according to two of the three readers’ interpretations (all p ≤ 0.001). Conclusion Applications of optimal time intervals and kinetic patterns show promise in differentiation of benign and malignant breast lesions on CEDM. |
| first_indexed | 2024-04-13T08:34:35Z |
| format | Article |
| id | doaj.art-7a3b914f6f7b4914b7383857f55c59b1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T08:34:35Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7a3b914f6f7b4914b7383857f55c59b12022-12-22T02:54:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01159Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogramJer-Shyung HuangHuay-Ben PanTsung-Lung YangBao-Hui HungChia-Ling ChiangMeng-Yuan TsaiChen-Pin ChouAzra AlizadPurpose To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM). Methods Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at 2, 3, 4, 7, and 10 min after injection of contrast agent. Three readers visually and semi-quantitatively analyzed the enhancement of suspicious lesions. The kinetic pattern of each lesion was classified as persistent, plateau, or washout over two time intervals, 2–4 min and 2–10 min, by comparing the signal intensity at the first time interval with that at the second. Results There were 73 malignant and 75 benign lesions in 148 patients (mean age: 52 years). Benign and malignant breast lesions showed the highest signal intensity at 3 min and 2 min, respectively. Average areas under receiver operating characteristic (ROC) curve for diagnostic accuracy based on lesion enhancement at different time points were 0.73 at 2 min, 0.72 at 3 min, 0.69 at 4 min, 0.67 at 7 min, and 0.64 at 10 min. Diagnostic performance was significantly better at 2, 3, and 4 min than at 7 and 10 min (all p < 0.05). A washout kinetic pattern was significantly associated with malignant lesions at 2–4 min and 2–10 min frames according to two of the three readers’ interpretations (all p ≤ 0.001). Conclusion Applications of optimal time intervals and kinetic patterns show promise in differentiation of benign and malignant breast lesions on CEDM.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498093/?tool=EBI |
| spellingShingle | Jer-Shyung Huang Huay-Ben Pan Tsung-Lung Yang Bao-Hui Hung Chia-Ling Chiang Meng-Yuan Tsai Chen-Pin Chou Azra Alizad Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram PLoS ONE |
| title | Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram |
| title_full | Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram |
| title_fullStr | Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram |
| title_full_unstemmed | Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram |
| title_short | Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram |
| title_sort | kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498093/?tool=EBI |
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