Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma
Abstract Background Neurotrauma is a worldwide public health problem which can be divided into primary and secondary damge. The primary damge is caused by external forces and triggers the overproduction of peroxides and superoxides, leading to long-lasting secondary damage including oxidative stress...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01071-4 |
| _version_ | 1828746825576742912 |
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| author | Yunguang Zhang Si Sun Haile Liu Qinjuan Ren Wenting Hao Qi Xin Jiangang Xu Hao Wang Xiao-Dong Zhang |
| author_facet | Yunguang Zhang Si Sun Haile Liu Qinjuan Ren Wenting Hao Qi Xin Jiangang Xu Hao Wang Xiao-Dong Zhang |
| author_sort | Yunguang Zhang |
| collection | DOAJ |
| description | Abstract Background Neurotrauma is a worldwide public health problem which can be divided into primary and secondary damge. The primary damge is caused by external forces and triggers the overproduction of peroxides and superoxides, leading to long-lasting secondary damage including oxidative stress, wound infection and immunological reactions. The emerging catalysts have shown great potential in the treatment of brain injury and neurogenic inflammation, but are limited to biosafety issues and delivery efficiency. Results Herein, we proposed the noninvasive delivery route to brain trauma by employing highly active gold clusters with enzyme-like activity to achieve the early intervention. The decomposition rate to H2O2 of the ultrasmall gold clusters is 10 times that of glassy carbon (GC) electrodes, indicating excellent catalytic activity. The gold clusters can relieve the oxidative stress and decrease the excessive O2 ·− and H2O2 both in vitro and in vivo. Besides, gold clusters can accelerate the wound healing of brain trauma and alleviate inflammation via inhibiting the activation of astrocytes and microglia through noninvasive adminstration. decrease the peroxide and superoxide of brain tissue. Conclusions Present work shows noninvasive treatment is a promising route for early intervention of brain trauma. |
| first_indexed | 2024-04-14T04:31:43Z |
| format | Article |
| id | doaj.art-7a3e2281a5154208bde5aa8864387762 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T04:31:43Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-7a3e2281a5154208bde5aa88643877622022-12-22T02:12:02ZengBMCJournal of Nanobiotechnology1477-31552021-10-0119111310.1186/s12951-021-01071-4Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotraumaYunguang Zhang0Si Sun1Haile Liu2Qinjuan Ren3Wenting Hao4Qi Xin5Jiangang Xu6Hao Wang7Xiao-Dong Zhang8School of Science, Xi’an University of Posts and TelecommunicationsTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin UniversityTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin UniversityTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin UniversityTianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin UniversityTianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin UniversitySchool of Science, Xi’an University of Posts and TelecommunicationsTianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin UniversityTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin UniversityAbstract Background Neurotrauma is a worldwide public health problem which can be divided into primary and secondary damge. The primary damge is caused by external forces and triggers the overproduction of peroxides and superoxides, leading to long-lasting secondary damage including oxidative stress, wound infection and immunological reactions. The emerging catalysts have shown great potential in the treatment of brain injury and neurogenic inflammation, but are limited to biosafety issues and delivery efficiency. Results Herein, we proposed the noninvasive delivery route to brain trauma by employing highly active gold clusters with enzyme-like activity to achieve the early intervention. The decomposition rate to H2O2 of the ultrasmall gold clusters is 10 times that of glassy carbon (GC) electrodes, indicating excellent catalytic activity. The gold clusters can relieve the oxidative stress and decrease the excessive O2 ·− and H2O2 both in vitro and in vivo. Besides, gold clusters can accelerate the wound healing of brain trauma and alleviate inflammation via inhibiting the activation of astrocytes and microglia through noninvasive adminstration. decrease the peroxide and superoxide of brain tissue. Conclusions Present work shows noninvasive treatment is a promising route for early intervention of brain trauma.https://doi.org/10.1186/s12951-021-01071-4Gold clustersCatalytic activityTraumatic brain injuryNoninvasive administration |
| spellingShingle | Yunguang Zhang Si Sun Haile Liu Qinjuan Ren Wenting Hao Qi Xin Jiangang Xu Hao Wang Xiao-Dong Zhang Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma Journal of Nanobiotechnology Gold clusters Catalytic activity Traumatic brain injury Noninvasive administration |
| title | Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma |
| title_full | Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma |
| title_fullStr | Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma |
| title_full_unstemmed | Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma |
| title_short | Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma |
| title_sort | catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma |
| topic | Gold clusters Catalytic activity Traumatic brain injury Noninvasive administration |
| url | https://doi.org/10.1186/s12951-021-01071-4 |
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