LYMPHATIC SYSTEM: A FORGOTTEN AREA?
Development of new methods of visualization of the lymphatic system and in the treatment of several pathologies associated with impaired lymph fl ow. The lymphatic system is an integral part of the circulation. One of the main functions of the lymphatic system is to transport residual interstitial f...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2016-11-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/681 |
| _version_ | 1797872005311102976 |
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| author | G. P. Itkin M. G. Itkin |
| author_facet | G. P. Itkin M. G. Itkin |
| author_sort | G. P. Itkin |
| collection | DOAJ |
| description | Development of new methods of visualization of the lymphatic system and in the treatment of several pathologies associated with impaired lymph fl ow. The lymphatic system is an integral part of the circulation. One of the main functions of the lymphatic system is to transport residual interstitial fl uid from the tissue back to the venous system. Despite growing recognition of the role of the lymphatic system in many disease processes, the techniques for imaging and interventions on the lymphatic system have lagged behind the well-developed methods for imaging and interventions on the cardiovascular systems. This is primarily due to small size and variability in anatomy of the lymphatic vessels, and diffi culty of introducing contrast into lymphatic ducts. Due to lack of imaging and intervention options, the fl ow function of the lymphatic system was relatively ignored over the last few decades. Recently, there has been resurgence in the interest in the fl ow function of the interventions on the lymphatic system with the development of percutaneous minimally invasive techniques, such as thoracic duct embolization, to treat life threatening lymphatic leaks. Our group recently introduced two new methods of lymphatic imaging: intranodal lymphangiography and dynamic contrast MR lymphangiography. These methods have allowed further understanding of lymphatic anatomy, pathophysiology, lymphodynamics, as well as provided guidance for novel minimally invasive lymphatic interventions. Using new techniques, the group discovered the causes and then developed treatments for several fatal conditions effecting single ventricle patients including plastic bronchitis and protein loosing enteropathy. Treatment for other conditions has evolved as well including congenital lymphodysplasia, chylothorax, and chylous ascites. The study of the liver lymphatic system has been little explored despite its signifi cant relevance as exampled in ascites formation in association with cirrhosis, one of the most recognized clinical manifestations of lymphatic vascular system disorders. Liver lymphangiogram is an additional minimally invasive technique that allows visualization of the liver lymphatics. Embolization of the liver lymphatic system has been proven to be curative for liver lymphorrea. Due to the lack of the imaging ability of the lymphatic system the understanding of these relationships lacked. Intranodal lymphangiogram, and liver lymphangiograms are one of the fi rst steps in attempt to understand these relationships. Embolization of the lymphatic system provides the opportunity to treat the abnormal lymphatic fl ows in conditions such as pulmonary lymphatic perfusion syndrome, liver cirrhosis, cardiac failure. |
| first_indexed | 2024-04-10T00:53:04Z |
| format | Article |
| id | doaj.art-7a40b5dd4a594370ab2b05144a46033b |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:53:04Z |
| publishDate | 2016-11-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-7a40b5dd4a594370ab2b05144a46033b2023-03-13T10:37:23ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912016-11-0118314515710.15825/1995-1191-2016-3-145-157571LYMPHATIC SYSTEM: A FORGOTTEN AREA?G. P. Itkin0M. G. Itkin1V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation, MoscowUniversity of Pennsylvania, The Children’s Hospital of Philadelphia (PA), PhiladelphiaDevelopment of new methods of visualization of the lymphatic system and in the treatment of several pathologies associated with impaired lymph fl ow. The lymphatic system is an integral part of the circulation. One of the main functions of the lymphatic system is to transport residual interstitial fl uid from the tissue back to the venous system. Despite growing recognition of the role of the lymphatic system in many disease processes, the techniques for imaging and interventions on the lymphatic system have lagged behind the well-developed methods for imaging and interventions on the cardiovascular systems. This is primarily due to small size and variability in anatomy of the lymphatic vessels, and diffi culty of introducing contrast into lymphatic ducts. Due to lack of imaging and intervention options, the fl ow function of the lymphatic system was relatively ignored over the last few decades. Recently, there has been resurgence in the interest in the fl ow function of the interventions on the lymphatic system with the development of percutaneous minimally invasive techniques, such as thoracic duct embolization, to treat life threatening lymphatic leaks. Our group recently introduced two new methods of lymphatic imaging: intranodal lymphangiography and dynamic contrast MR lymphangiography. These methods have allowed further understanding of lymphatic anatomy, pathophysiology, lymphodynamics, as well as provided guidance for novel minimally invasive lymphatic interventions. Using new techniques, the group discovered the causes and then developed treatments for several fatal conditions effecting single ventricle patients including plastic bronchitis and protein loosing enteropathy. Treatment for other conditions has evolved as well including congenital lymphodysplasia, chylothorax, and chylous ascites. The study of the liver lymphatic system has been little explored despite its signifi cant relevance as exampled in ascites formation in association with cirrhosis, one of the most recognized clinical manifestations of lymphatic vascular system disorders. Liver lymphangiogram is an additional minimally invasive technique that allows visualization of the liver lymphatics. Embolization of the liver lymphatic system has been proven to be curative for liver lymphorrea. Due to the lack of the imaging ability of the lymphatic system the understanding of these relationships lacked. Intranodal lymphangiogram, and liver lymphangiograms are one of the fi rst steps in attempt to understand these relationships. Embolization of the lymphatic system provides the opportunity to treat the abnormal lymphatic fl ows in conditions such as pulmonary lymphatic perfusion syndrome, liver cirrhosis, cardiac failure.https://journal.transpl.ru/vtio/article/view/681lymphatic systemimaginginterventionslymphatic ductsminimally invasive techniqueslymphangiographymrplastic bronchitisenteropathyliver lymphorrea |
| spellingShingle | G. P. Itkin M. G. Itkin LYMPHATIC SYSTEM: A FORGOTTEN AREA? Vestnik Transplantologii i Iskusstvennyh Organov lymphatic system imaging interventions lymphatic ducts minimally invasive techniques lymphangiography mr plastic bronchitis enteropathy liver lymphorrea |
| title | LYMPHATIC SYSTEM: A FORGOTTEN AREA? |
| title_full | LYMPHATIC SYSTEM: A FORGOTTEN AREA? |
| title_fullStr | LYMPHATIC SYSTEM: A FORGOTTEN AREA? |
| title_full_unstemmed | LYMPHATIC SYSTEM: A FORGOTTEN AREA? |
| title_short | LYMPHATIC SYSTEM: A FORGOTTEN AREA? |
| title_sort | lymphatic system a forgotten area |
| topic | lymphatic system imaging interventions lymphatic ducts minimally invasive techniques lymphangiography mr plastic bronchitis enteropathy liver lymphorrea |
| url | https://journal.transpl.ru/vtio/article/view/681 |
| work_keys_str_mv | AT gpitkin lymphaticsystemaforgottenarea AT mgitkin lymphaticsystemaforgottenarea |