The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma
Abstract Background Numerous studies have addressed lymphovascular invasion (LVI) in patients with thoracic oesophageal squamous cell carcinoma (ESCC); however, little is known about the individual roles of lymphatic invasion (LI) and vascular invasion (VI). We aimed to analyse the prognostic signif...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-021-02458-1 |
| _version_ | 1798026439311753216 |
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| author | Yu Ma Xi Yao Zhenzhen Li Jie Chen Wensheng Li Hongtao Wang Lanjun Zhang Jianfei Zhu |
| author_facet | Yu Ma Xi Yao Zhenzhen Li Jie Chen Wensheng Li Hongtao Wang Lanjun Zhang Jianfei Zhu |
| author_sort | Yu Ma |
| collection | DOAJ |
| description | Abstract Background Numerous studies have addressed lymphovascular invasion (LVI) in patients with thoracic oesophageal squamous cell carcinoma (ESCC); however, little is known about the individual roles of lymphatic invasion (LI) and vascular invasion (VI). We aimed to analyse the prognostic significance of LI and VI in patients with thoracic ESCC from a single centre. Methods This retrospective study included 396 patients with thoracic ESCC who underwent oesophagectomy and lymphadenectomy in our hospital. The relationship between LI, VI and the other clinical features was analysed, and disease-free survival (DFS) was calculated. Survival analysis was performed by univariate and multivariate statistics. Results Briefly, VI and LI were present in 25.8% (102 of 396) and 23.7% (94 of 396) of ESCC patients, respectively, with 9.15% patients presenting both LI and VI; the remaining patients did not present LI or VI. We found that LI was significantly associated with pN stage (P<0.001) and pTNM stage (P<0.001), and similar results were found in VI. Moreover, survival analysis showed that pT stage (P<0.001), pN stage (P=0.001), pTNM stage (p<0.001), VI (P=0.001) and LI (P<0.001) were associated with DFS in ESCC. Furthermore, multivariate analysis suggested that pT stage (RR=1.4, P =0.032), pN stage (RR=1.9, P<0.001) and LI (RR=1.5, P=0.008) were independent predictive factors for DFS. Finally, relapse was observed in 110 patients (lymph node metastasis, 78 and distant, 32) and 147 patients with cancer-related deaths. Subanalysis showed that LI-positive patients had higher lymph node metastasis, although there was no significant difference (32.1% vs. 15.6%, P=0.100). Conclusions LI and VI were common in ESCC; they were all survival predictors for patients with ESCC, and LI was independent. Patients with positive LI were more likely to suffer lymph node metastasis. |
| first_indexed | 2024-04-11T18:35:36Z |
| format | Article |
| id | doaj.art-7a437569f33b46989e48123bce7220ed |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-11T18:35:36Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-7a437569f33b46989e48123bce7220ed2022-12-22T04:09:17ZengBMCWorld Journal of Surgical Oncology1477-78192022-01-012011910.1186/s12957-021-02458-1The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinomaYu Ma0Xi Yao1Zhenzhen Li2Jie Chen3Wensheng Li4Hongtao Wang5Lanjun Zhang6Jianfei Zhu7Department of Pathology, Shaanxi Provincial People’s HospitalDepartment of Anesthesiology, Shaanxi Provincial People’s HospitalDepartment of Pathology, Shaanxi Provincial People’s HospitalDepartment of Pathology, Shaanxi Provincial People’s HospitalDepartment of Pathology, Shaanxi Provincial People’s HospitalDepartment of Thoracic Surgery, Shaanxi Provincial People’s HospitalDepartment of Thoracic Surgery, Sun Yat-sen University Cancer CenterDepartment of Thoracic Surgery, Shaanxi Provincial People’s HospitalAbstract Background Numerous studies have addressed lymphovascular invasion (LVI) in patients with thoracic oesophageal squamous cell carcinoma (ESCC); however, little is known about the individual roles of lymphatic invasion (LI) and vascular invasion (VI). We aimed to analyse the prognostic significance of LI and VI in patients with thoracic ESCC from a single centre. Methods This retrospective study included 396 patients with thoracic ESCC who underwent oesophagectomy and lymphadenectomy in our hospital. The relationship between LI, VI and the other clinical features was analysed, and disease-free survival (DFS) was calculated. Survival analysis was performed by univariate and multivariate statistics. Results Briefly, VI and LI were present in 25.8% (102 of 396) and 23.7% (94 of 396) of ESCC patients, respectively, with 9.15% patients presenting both LI and VI; the remaining patients did not present LI or VI. We found that LI was significantly associated with pN stage (P<0.001) and pTNM stage (P<0.001), and similar results were found in VI. Moreover, survival analysis showed that pT stage (P<0.001), pN stage (P=0.001), pTNM stage (p<0.001), VI (P=0.001) and LI (P<0.001) were associated with DFS in ESCC. Furthermore, multivariate analysis suggested that pT stage (RR=1.4, P =0.032), pN stage (RR=1.9, P<0.001) and LI (RR=1.5, P=0.008) were independent predictive factors for DFS. Finally, relapse was observed in 110 patients (lymph node metastasis, 78 and distant, 32) and 147 patients with cancer-related deaths. Subanalysis showed that LI-positive patients had higher lymph node metastasis, although there was no significant difference (32.1% vs. 15.6%, P=0.100). Conclusions LI and VI were common in ESCC; they were all survival predictors for patients with ESCC, and LI was independent. Patients with positive LI were more likely to suffer lymph node metastasis.https://doi.org/10.1186/s12957-021-02458-1Oesophageal squamous cell carcinomaLymphatic invasionVascular invasionDisease-free survivalLymph node metastasis |
| spellingShingle | Yu Ma Xi Yao Zhenzhen Li Jie Chen Wensheng Li Hongtao Wang Lanjun Zhang Jianfei Zhu The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma World Journal of Surgical Oncology Oesophageal squamous cell carcinoma Lymphatic invasion Vascular invasion Disease-free survival Lymph node metastasis |
| title | The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma |
| title_full | The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma |
| title_fullStr | The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma |
| title_full_unstemmed | The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma |
| title_short | The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma |
| title_sort | role of vascular invasion and lymphatic invasion in predicting recurrent thoracic oesophageal squamous cell carcinoma |
| topic | Oesophageal squamous cell carcinoma Lymphatic invasion Vascular invasion Disease-free survival Lymph node metastasis |
| url | https://doi.org/10.1186/s12957-021-02458-1 |
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