Evaluation of mean platelet volume and platelet count in patients with schizophrenia
Introduction: Compared to the general population, cardiovascular diseases are more common in schizophrenia patients and the mortality rate is higher than the general population. One of the explanations for increased cardiovascular events in patients with schizophrenia is the increase in platelet act...
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| Format: | Article |
| Language: | English |
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SERNEV
2018-08-01
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| Series: | Family Practice and Palliative Care |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/541854 |
| _version_ | 1797244634808713216 |
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| author | Ibrahim Eren Yusuf Cokunlu Bilge Cetin Ilhan Memduha Aydin Tuba Serife Elmas |
| author_facet | Ibrahim Eren Yusuf Cokunlu Bilge Cetin Ilhan Memduha Aydin Tuba Serife Elmas |
| author_sort | Ibrahim Eren |
| collection | DOAJ |
| description | Introduction: Compared to the general
population, cardiovascular diseases are more common in schizophrenia patients
and the mortality rate is higher than the general population. One of the
explanations for increased cardiovascular events in patients with schizophrenia
is the increase in platelet activity. Platelets are essential for progression of
atherosclerotic lesions, plaque destabilization, and thrombus formation. Mean
platelet volume (MPV) is a measure of platelet size and a good marker of
platelet function and activation, which increases in cardiovascular diseases.
MPV is routinely reported during complete blood count analysis. The aim of the
present study was to evaluate MPV values of patients with schizophrenia.
Methods: In this retrospective study,
hospital-records of the patients who were consecutively admitted to psychiatry
inpatient clinic between January 2015 and January 2017 with the diagnosis of
schizophrenia were reviewed. Healthy subjects with no personal history of
psychiatric disorder were included as a control group.
Results: A total of 100 (59 female, 41 male)
schizophrenic patients who had been consecutively admitted to the psychiatry
inpatient clinic and 37
(20 female, 17 male) healthy controls were included in this retrospective study. There
were no significant differences between the patient group and control group in
the terms of age (mean age patient group vs control group: 37.72 vs 35.03, p=0.081) and sex
(p=0.603). Body mass index (BMI) was
found to be significantly different between groups, higher in the patient group
(p=0.001). The MPV was found to be
significantly higher in patient group compared with the control group (MPV,
patient group vs control group: 10.34 fL vs 9.97 fL, p=0.041). Platelet count (PC) was significantly lower in the patient group (PC,
patient group vs control group: 234.36 vs 267.38, p=0.008) There
was no correlation between MPV and BMI (p=0.354, r=0.10), and
duration of illness (p=0.530,
r=0.06).
Conclusions: As a result,
increased MPV and decreased PC were found in a group of schizophrenic patient
in this study. Since increased MPV and decreased PC are evaluated as risk
factors for cardiovascular diseases in the general population, they can also be considered as a
predictor of risk factors for cardiovascular diseases that are more frequently encountered in schizophrenia. |
| first_indexed | 2024-03-08T18:58:59Z |
| format | Article |
| id | doaj.art-7a43c5be222b420a80615585bbd60e9a |
| institution | Directory Open Access Journal |
| issn | 2459-1505 |
| language | English |
| last_indexed | 2024-04-24T19:14:08Z |
| publishDate | 2018-08-01 |
| publisher | SERNEV |
| record_format | Article |
| series | Family Practice and Palliative Care |
| spelling | doaj.art-7a43c5be222b420a80615585bbd60e9a2024-03-26T08:15:56ZengSERNEVFamily Practice and Palliative Care2459-15052018-08-013210210710.22391/fppc.401101544Evaluation of mean platelet volume and platelet count in patients with schizophreniaIbrahim Eren0Yusuf Cokunlu1Bilge Cetin Ilhan2Memduha Aydin3Tuba Serife Elmas4Konya Training and Research Hospital, Department of Psychiatry, KonyaKonya Training and Research Hospital, Department of Psychiatry, KonyaKonya Training and Research Hospital, Department of Psychiatry, KonyaSelcuk University, Faculty of Medicine, Department of Psychiatry, KonyaKonya Training and Research Hospital, Department of Psychiatry, KonyaIntroduction: Compared to the general population, cardiovascular diseases are more common in schizophrenia patients and the mortality rate is higher than the general population. One of the explanations for increased cardiovascular events in patients with schizophrenia is the increase in platelet activity. Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombus formation. Mean platelet volume (MPV) is a measure of platelet size and a good marker of platelet function and activation, which increases in cardiovascular diseases. MPV is routinely reported during complete blood count analysis. The aim of the present study was to evaluate MPV values of patients with schizophrenia. Methods: In this retrospective study, hospital-records of the patients who were consecutively admitted to psychiatry inpatient clinic between January 2015 and January 2017 with the diagnosis of schizophrenia were reviewed. Healthy subjects with no personal history of psychiatric disorder were included as a control group. Results: A total of 100 (59 female, 41 male) schizophrenic patients who had been consecutively admitted to the psychiatry inpatient clinic and 37 (20 female, 17 male) healthy controls were included in this retrospective study. There were no significant differences between the patient group and control group in the terms of age (mean age patient group vs control group: 37.72 vs 35.03, p=0.081) and sex (p=0.603). Body mass index (BMI) was found to be significantly different between groups, higher in the patient group (p=0.001). The MPV was found to be significantly higher in patient group compared with the control group (MPV, patient group vs control group: 10.34 fL vs 9.97 fL, p=0.041). Platelet count (PC) was significantly lower in the patient group (PC, patient group vs control group: 234.36 vs 267.38, p=0.008) There was no correlation between MPV and BMI (p=0.354, r=0.10), and duration of illness (p=0.530, r=0.06). Conclusions: As a result, increased MPV and decreased PC were found in a group of schizophrenic patient in this study. Since increased MPV and decreased PC are evaluated as risk factors for cardiovascular diseases in the general population, they can also be considered as a predictor of risk factors for cardiovascular diseases that are more frequently encountered in schizophrenia.https://dergipark.org.tr/en/download/article-file/541854kardiyovasküler hastalıklarortalama trombosit hacmişizofrenicardiovascular diseasesmean platelet volumeschizophrenia |
| spellingShingle | Ibrahim Eren Yusuf Cokunlu Bilge Cetin Ilhan Memduha Aydin Tuba Serife Elmas Evaluation of mean platelet volume and platelet count in patients with schizophrenia Family Practice and Palliative Care kardiyovasküler hastalıklar ortalama trombosit hacmi şizofreni cardiovascular diseases mean platelet volume schizophrenia |
| title | Evaluation of mean platelet volume and platelet count in patients with schizophrenia |
| title_full | Evaluation of mean platelet volume and platelet count in patients with schizophrenia |
| title_fullStr | Evaluation of mean platelet volume and platelet count in patients with schizophrenia |
| title_full_unstemmed | Evaluation of mean platelet volume and platelet count in patients with schizophrenia |
| title_short | Evaluation of mean platelet volume and platelet count in patients with schizophrenia |
| title_sort | evaluation of mean platelet volume and platelet count in patients with schizophrenia |
| topic | kardiyovasküler hastalıklar ortalama trombosit hacmi şizofreni cardiovascular diseases mean platelet volume schizophrenia |
| url | https://dergipark.org.tr/en/download/article-file/541854 |
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