Role of the Extracellular Matrix in Loss of Muscle Force With Age and Unloading Using Magnetic Resonance Imaging, Biochemical Analysis, and Computational Models

Role of the Extracellular Matrix in Loss of Muscle Force With Age and Unloading Using Magnetic Resonance Imaging, Biochemical Analysis, and Computational Models

The focus of this review is the application of advanced MRI to study the effect of aging and disuse related remodeling of the extracellular matrix (ECM) on force transmission in the human musculoskeletal system. Structural MRI includes (i) ultra-low echo times (UTE) maps to visualize and quantify th...

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Bibliographic Details
Main Authors: Usha Sinha, Vadim Malis, Jiun-Shyan Chen, Robert Csapo, Ryuta Kinugasa, Marco Vincenzo Narici, Shantanu Sinha
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
extracellular matrix
age and disuse related muscle force loss
structural muscle MRI
strain imaging
lateral transmission of force
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00626/full

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