Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental Study
The impact of nano-selenium supplementation on lipid metabolism, liver enzymes, renal function, and protein levels in male lambs was investigated in this study during a 60-day period. Lambs were divided into two groups - control and experimental, which were administered nanoselenium orally at a dosa...
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| Format: | Article |
| Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2023-12-01
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| Series: | RUDN Journal of Agronomy and Animal Industries |
| Subjects: | |
| Online Access: | https://agrojournal.rudn.ru/agronomy/article/viewFile/19904/16358 |
| _version_ | 1797783870157881344 |
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| author | Karwan A.H. Aljaf Marina N. Bolshakova |
| author_facet | Karwan A.H. Aljaf Marina N. Bolshakova |
| author_sort | Karwan A.H. Aljaf |
| collection | DOAJ |
| description | The impact of nano-selenium supplementation on lipid metabolism, liver enzymes, renal function, and protein levels in male lambs was investigated in this study during a 60-day period. Lambs were divided into two groups - control and experimental, which were administered nanoselenium orally at a dosage of 0.5 mg/ kg of feed once a day, daily. Each group consisted of five male lambs. According to the findings, cholesterol levels dropped significantly at days 45 (P 0.01) and 60 (P 0.05), whereas triglyceride levels significantly rose at days 15 and 30 (P 0.01). Throughout the trial, the levels of uric acid and creatinine were constant. At days 15 and 60, aspartate aminotransferase (AST) levels were significantly decreased (P 0.05), while at days 45 and 60, alkaline phosphatase (ALP) levels declined (P 0.01 and P 0.05, respectively). At days 15 and 30, albumin levels dropped significantly (0.05), but day 60 saw an increase in globulin levels significantly (P 0.05). The drop in AST and ALP levels might be a sign that liver function has possibly improved. However, the drop in albumin levels and rise in globulin levels raise the possibility that taking nano-selenium supplements may affect how proteins are metabolized. The findings of this study concluded that the effects of nano-selenium supplementation on lipid metabolism, liver enzymes, renal function, and protein levels in male lambs were time-dependent. In addition to possible improvements in liver function based on decreased AST and ALP levels and changes in albumin and globulin levels, the study also noticed an initial transient increase in triglyceride levels that was followed by a decline in cholesterol levels. To determine the time-dependent changes in liver function, liver enzymes, as well as renal function in response to nano-selenium supplementation in male lambs was objective of this study. |
| first_indexed | 2024-03-13T00:32:01Z |
| format | Article |
| id | doaj.art-7a47bb49b0cf4fa7a3f6b957263c3a02 |
| institution | Directory Open Access Journal |
| issn | 2312-797X 2312-7988 |
| language | English |
| last_indexed | 2024-03-13T00:32:01Z |
| publishDate | 2023-12-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Agronomy and Animal Industries |
| spelling | doaj.art-7a47bb49b0cf4fa7a3f6b957263c3a022023-07-10T12:16:34ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Agronomy and Animal Industries2312-797X2312-79882023-12-0118223024010.22363/2312-797X-2023-18-2-230-24117024Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental StudyKarwan A.H. Aljaf0https://orcid.org/0000-0001-8522-6639Marina N. Bolshakova1https://orcid.org/0000-0002-4553-7974RUDN UniversityRUDN UniversityThe impact of nano-selenium supplementation on lipid metabolism, liver enzymes, renal function, and protein levels in male lambs was investigated in this study during a 60-day period. Lambs were divided into two groups - control and experimental, which were administered nanoselenium orally at a dosage of 0.5 mg/ kg of feed once a day, daily. Each group consisted of five male lambs. According to the findings, cholesterol levels dropped significantly at days 45 (P 0.01) and 60 (P 0.05), whereas triglyceride levels significantly rose at days 15 and 30 (P 0.01). Throughout the trial, the levels of uric acid and creatinine were constant. At days 15 and 60, aspartate aminotransferase (AST) levels were significantly decreased (P 0.05), while at days 45 and 60, alkaline phosphatase (ALP) levels declined (P 0.01 and P 0.05, respectively). At days 15 and 30, albumin levels dropped significantly (0.05), but day 60 saw an increase in globulin levels significantly (P 0.05). The drop in AST and ALP levels might be a sign that liver function has possibly improved. However, the drop in albumin levels and rise in globulin levels raise the possibility that taking nano-selenium supplements may affect how proteins are metabolized. The findings of this study concluded that the effects of nano-selenium supplementation on lipid metabolism, liver enzymes, renal function, and protein levels in male lambs were time-dependent. In addition to possible improvements in liver function based on decreased AST and ALP levels and changes in albumin and globulin levels, the study also noticed an initial transient increase in triglyceride levels that was followed by a decline in cholesterol levels. To determine the time-dependent changes in liver function, liver enzymes, as well as renal function in response to nano-selenium supplementation in male lambs was objective of this study.https://agrojournal.rudn.ru/agronomy/article/viewFile/19904/16358lipid metabolismliver enzymesprotein levelsaspartate aminotransferasealkaline phosphatase |
| spellingShingle | Karwan A.H. Aljaf Marina N. Bolshakova Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental Study RUDN Journal of Agronomy and Animal Industries lipid metabolism liver enzymes protein levels aspartate aminotransferase alkaline phosphatase |
| title | Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental Study |
| title_full | Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental Study |
| title_fullStr | Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental Study |
| title_full_unstemmed | Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental Study |
| title_short | Nano-Selenium-Mediated Alterations in Lipid Profile, Liver and Renal Functions, and Protein Parameters in Male Lambs: An Experimental Study |
| title_sort | nano selenium mediated alterations in lipid profile liver and renal functions and protein parameters in male lambs an experimental study |
| topic | lipid metabolism liver enzymes protein levels aspartate aminotransferase alkaline phosphatase |
| url | https://agrojournal.rudn.ru/agronomy/article/viewFile/19904/16358 |
| work_keys_str_mv | AT karwanahaljaf nanoseleniummediatedalterationsinlipidprofileliverandrenalfunctionsandproteinparametersinmalelambsanexperimentalstudy AT marinanbolshakova nanoseleniummediatedalterationsinlipidprofileliverandrenalfunctionsandproteinparametersinmalelambsanexperimentalstudy |