Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

Summary: Studies defining normal and disrupted human neural crest cell development have been challenging given its early timing and intricacy of development. Consequently, insight into the early disruptive events causing a neural crest related disease such as pediatric cancer neuroblastoma is limite...

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Bibliographic Details
Main Authors: Stéphane Van Haver, Yujie Fan, Sarah-Lee Bekaert, Celine Everaert, Wouter Van Loocke, Vittorio Zanzani, Joke Deschildre, Inés Fernandez Maestre, Adrianna Amaro, Vanessa Vermeirssen, Katleen De Preter, Ting Zhou, Alex Kentsis, Lorenz Studer, Frank Speleman, Stephen S. Roberts
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Cancer
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223021739

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