Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related Cirrhosis
ObjectivesThis research amid to elucidate the disease stage-specific spatial patterns and the probable sequences of gray matter (GM) deterioration as well as the causal relationship among structural network components in hepatitis B virus-related cirrhosis (HBV-RC) patients.MethodsTotally 30 HBV-RC...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.849571/full |
| _version_ | 1818544495221800960 |
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| author | Shiwei Lin Shiwei Lin Zheng Guo Shengli Chen Shengli Chen Xiaoshan Lin Min Ye Min Ye Yingwei Qiu |
| author_facet | Shiwei Lin Shiwei Lin Zheng Guo Shengli Chen Shengli Chen Xiaoshan Lin Min Ye Min Ye Yingwei Qiu |
| author_sort | Shiwei Lin |
| collection | DOAJ |
| description | ObjectivesThis research amid to elucidate the disease stage-specific spatial patterns and the probable sequences of gray matter (GM) deterioration as well as the causal relationship among structural network components in hepatitis B virus-related cirrhosis (HBV-RC) patients.MethodsTotally 30 HBV-RC patients and 38 healthy controls (HC) were recruited for this study. High-resolution T1-weighted magnetic resonance imaging and psychometric hepatic encephalopathy score (PHES) were evaluated in all participants. Voxel-based morphometry (VBM), structural covariance network (SCN), and causal SCN (CaSCN) were applied to identify the disease stage-specific GM abnormalities in morphology and network, as well as their causal relationship.ResultsCompared to HC (0.443 ± 0.073 cm3), the thalamus swelled significantly in the no minimal hepatic encephalopathy (NMHE) stage (0.607 ± 0.154 cm3, p <0.05, corrected) and further progressed and expanded to the bilateral basal ganglia, the cortices, and the cerebellum in the MHE stage (p < 0.05, corrected). Furthermore, the thalamus swelling had a causal effect on other parts of cortex-basal ganglia-thalamus circuits (p < 0.05, corrected), which was negatively correlated with cognitive performance (r = −0.422, p < 0.05). Moreover, the thalamus-related SCN also displayed progressive deterioration as the disease advanced in HBV-RC patients (p < 0.05, corrected).ConclusionProgressive deterioration of GM morphology and SCN exists in HBV-RC patients during advanced disease, displaying thalamus-related causal effects. These findings indicate that bilateral thalamus morphology as well as the thalamus-related network may serve as an in vivo biomarker for monitoring the progression of the disease in HBV-RC patients. |
| first_indexed | 2024-12-11T22:49:14Z |
| format | Article |
| id | doaj.art-7a4d1bb69405446f9e08a2087b97866a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T22:49:14Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-7a4d1bb69405446f9e08a2087b97866a2022-12-22T00:47:31ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.849571849571Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related CirrhosisShiwei Lin0Shiwei Lin1Zheng Guo2Shengli Chen3Shengli Chen4Xiaoshan Lin5Min Ye6Min Ye7Yingwei Qiu8Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, ChinaDepartment of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, ChinaDepartment of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaDepartment of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University Health Science Center, Shenzhen, ChinaDepartment of Geriatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, ChinaObjectivesThis research amid to elucidate the disease stage-specific spatial patterns and the probable sequences of gray matter (GM) deterioration as well as the causal relationship among structural network components in hepatitis B virus-related cirrhosis (HBV-RC) patients.MethodsTotally 30 HBV-RC patients and 38 healthy controls (HC) were recruited for this study. High-resolution T1-weighted magnetic resonance imaging and psychometric hepatic encephalopathy score (PHES) were evaluated in all participants. Voxel-based morphometry (VBM), structural covariance network (SCN), and causal SCN (CaSCN) were applied to identify the disease stage-specific GM abnormalities in morphology and network, as well as their causal relationship.ResultsCompared to HC (0.443 ± 0.073 cm3), the thalamus swelled significantly in the no minimal hepatic encephalopathy (NMHE) stage (0.607 ± 0.154 cm3, p <0.05, corrected) and further progressed and expanded to the bilateral basal ganglia, the cortices, and the cerebellum in the MHE stage (p < 0.05, corrected). Furthermore, the thalamus swelling had a causal effect on other parts of cortex-basal ganglia-thalamus circuits (p < 0.05, corrected), which was negatively correlated with cognitive performance (r = −0.422, p < 0.05). Moreover, the thalamus-related SCN also displayed progressive deterioration as the disease advanced in HBV-RC patients (p < 0.05, corrected).ConclusionProgressive deterioration of GM morphology and SCN exists in HBV-RC patients during advanced disease, displaying thalamus-related causal effects. These findings indicate that bilateral thalamus morphology as well as the thalamus-related network may serve as an in vivo biomarker for monitoring the progression of the disease in HBV-RC patients.https://www.frontiersin.org/articles/10.3389/fneur.2022.849571/fullcirrhosishepatic encephalopathyMRIgray matterthalamus |
| spellingShingle | Shiwei Lin Shiwei Lin Zheng Guo Shengli Chen Shengli Chen Xiaoshan Lin Min Ye Min Ye Yingwei Qiu Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related Cirrhosis Frontiers in Neurology cirrhosis hepatic encephalopathy MRI gray matter thalamus |
| title | Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related Cirrhosis |
| title_full | Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related Cirrhosis |
| title_fullStr | Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related Cirrhosis |
| title_full_unstemmed | Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related Cirrhosis |
| title_short | Progressive Brain Structural Impairment Assessed via Network and Causal Analysis in Patients With Hepatitis B Virus-Related Cirrhosis |
| title_sort | progressive brain structural impairment assessed via network and causal analysis in patients with hepatitis b virus related cirrhosis |
| topic | cirrhosis hepatic encephalopathy MRI gray matter thalamus |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.849571/full |
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