Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis
Despite growing evidence of the significant influence of blood-flow-restricted (BFR) training on different body functions, its impact on the vascular system, especially the arteries, is controversial. Therefore, the objective of our study was to analyze how BFR exercise, compared to other types of e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1601 |
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| author | Mikołaj Maga Agnieszka Wachsmann-Maga Krzysztof Batko Aleksandra Włodarczyk Paulina Kłapacz Jakub Krężel Natalia Szopa Agnieszka Sliwka |
| author_facet | Mikołaj Maga Agnieszka Wachsmann-Maga Krzysztof Batko Aleksandra Włodarczyk Paulina Kłapacz Jakub Krężel Natalia Szopa Agnieszka Sliwka |
| author_sort | Mikołaj Maga |
| collection | DOAJ |
| description | Despite growing evidence of the significant influence of blood-flow-restricted (BFR) training on different body functions, its impact on the vascular system, especially the arteries, is controversial. Therefore, the objective of our study was to analyze how BFR exercise, compared to other types of exercise without the restriction of blood flow, influences arterial functions and angiogenesis in adults. Studies comparing the effect of BFR versus non-BFR training on arterial parameters were divided into three categories: endothelial function, angiogenesis, and other vasculature functions. The search was based on Cochrane Library, PubMed<sup>®</sup>, and Embase, and 38 studies were included. The meta-analysis revealed a more significant improvement in flow-mediated dilatation (FMD) (<i>p</i> = 0.002) and the production of the primary angiogenesis biomarker vascular endothelial growth factor (VEGF) (<i>p</i> = 0.009) after BFR compared to non-BFR training (<i>p</i> = 0.002). The analysis of the pulse wave velocity, ankle-brachial index, systolic blood pressure, and heart rate did not show significant differences in changes between BFR and non-BFR training. The other parameters examined did not have sufficient data to be included in the meta-analysis. The results obtained present trends that suggest significant impacts of BFR training on endothelial functions and angiogenesis. There is still a lack of multicenter randomized clinical trials including many participants, and such studies are necessary to confirm the advantage of BFR over non-BFR activity. |
| first_indexed | 2024-03-11T02:44:50Z |
| format | Article |
| id | doaj.art-7a4d1cbfec12464db618788a5ee56e70 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:44:50Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7a4d1cbfec12464db618788a5ee56e702023-11-18T09:25:36ZengMDPI AGBiomedicines2227-90592023-05-01116160110.3390/biomedicines11061601Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-AnalysisMikołaj Maga0Agnieszka Wachsmann-Maga1Krzysztof Batko2Aleksandra Włodarczyk3Paulina Kłapacz4Jakub Krężel5Natalia Szopa6Agnieszka Sliwka7Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-008 Krakow, PolandClinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, PolandDepartment of Research and Design, Medicine Economy Law Society (MELS) Foundation, 30-040 Krakow, PolandDepartment of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, PolandClinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, PolandClinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, PolandDepartment of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, PolandDepartment of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-008 Krakow, PolandDespite growing evidence of the significant influence of blood-flow-restricted (BFR) training on different body functions, its impact on the vascular system, especially the arteries, is controversial. Therefore, the objective of our study was to analyze how BFR exercise, compared to other types of exercise without the restriction of blood flow, influences arterial functions and angiogenesis in adults. Studies comparing the effect of BFR versus non-BFR training on arterial parameters were divided into three categories: endothelial function, angiogenesis, and other vasculature functions. The search was based on Cochrane Library, PubMed<sup>®</sup>, and Embase, and 38 studies were included. The meta-analysis revealed a more significant improvement in flow-mediated dilatation (FMD) (<i>p</i> = 0.002) and the production of the primary angiogenesis biomarker vascular endothelial growth factor (VEGF) (<i>p</i> = 0.009) after BFR compared to non-BFR training (<i>p</i> = 0.002). The analysis of the pulse wave velocity, ankle-brachial index, systolic blood pressure, and heart rate did not show significant differences in changes between BFR and non-BFR training. The other parameters examined did not have sufficient data to be included in the meta-analysis. The results obtained present trends that suggest significant impacts of BFR training on endothelial functions and angiogenesis. There is still a lack of multicenter randomized clinical trials including many participants, and such studies are necessary to confirm the advantage of BFR over non-BFR activity.https://www.mdpi.com/2227-9059/11/6/1601blood-flow-restricted trainingvascular functionsangiogenesisendothelium |
| spellingShingle | Mikołaj Maga Agnieszka Wachsmann-Maga Krzysztof Batko Aleksandra Włodarczyk Paulina Kłapacz Jakub Krężel Natalia Szopa Agnieszka Sliwka Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis Biomedicines blood-flow-restricted training vascular functions angiogenesis endothelium |
| title | Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis |
| title_full | Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis |
| title_fullStr | Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis |
| title_full_unstemmed | Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis |
| title_short | Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis |
| title_sort | impact of blood flow restricted training on arterial functions and angiogenesis a systematic review with meta analysis |
| topic | blood-flow-restricted training vascular functions angiogenesis endothelium |
| url | https://www.mdpi.com/2227-9059/11/6/1601 |
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