B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes
Whereas autoimmune diseases are mediated primarily by T and B cells, auto-inflammatory syndromes (AIFS) involve natural killer cells, macrophages, mast cells, dendritic cells, different granulocyte subsets and complement components. In contrast to autoimmune diseases, the immune response of patients...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/24/4025 |
| _version_ | 1827641400146001920 |
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| author | Moncef Zouali |
| author_facet | Moncef Zouali |
| author_sort | Moncef Zouali |
| collection | DOAJ |
| description | Whereas autoimmune diseases are mediated primarily by T and B cells, auto-inflammatory syndromes (AIFS) involve natural killer cells, macrophages, mast cells, dendritic cells, different granulocyte subsets and complement components. In contrast to autoimmune diseases, the immune response of patients with AIFS is not associated with a breakdown of immune tolerance to self-antigens. Focusing on B lymphocyte subsets, this article offers a fresh perspective on the multiple cross-talks between both branches of innate and adaptive immunity in mounting coordinated signals that lead to AIFS. By virtue of their potential to play a role in adaptive immunity and to exert innate-like functions, B cells can be involved in both promoting inflammation and mitigating auto-inflammation in disorders that include mevalonate kinase deficiency syndrome, Kawasaki syndrome, inflammatory bone disorders, Schnitzler syndrome, Neuro-Behçet’s disease, and neuromyelitis optica spectrum disorder. Since there is a significant overlap between the pathogenic trajectories that culminate in autoimmune diseases, or AIFS, a more detailed understanding of their respective roles in the development of inflammation could lead to designing novel therapeutic avenues. |
| first_indexed | 2024-03-09T17:13:25Z |
| format | Article |
| id | doaj.art-7a4e426ad3e14864b0a2fd14a7bf7c83 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:13:25Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7a4e426ad3e14864b0a2fd14a7bf7c832023-11-24T13:54:31ZengMDPI AGCells2073-44092022-12-011124402510.3390/cells11244025B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory SyndromesMoncef Zouali0Graduate Institute of Biomedical Sciences, China Medical University, Taichung City 404, TaiwanWhereas autoimmune diseases are mediated primarily by T and B cells, auto-inflammatory syndromes (AIFS) involve natural killer cells, macrophages, mast cells, dendritic cells, different granulocyte subsets and complement components. In contrast to autoimmune diseases, the immune response of patients with AIFS is not associated with a breakdown of immune tolerance to self-antigens. Focusing on B lymphocyte subsets, this article offers a fresh perspective on the multiple cross-talks between both branches of innate and adaptive immunity in mounting coordinated signals that lead to AIFS. By virtue of their potential to play a role in adaptive immunity and to exert innate-like functions, B cells can be involved in both promoting inflammation and mitigating auto-inflammation in disorders that include mevalonate kinase deficiency syndrome, Kawasaki syndrome, inflammatory bone disorders, Schnitzler syndrome, Neuro-Behçet’s disease, and neuromyelitis optica spectrum disorder. Since there is a significant overlap between the pathogenic trajectories that culminate in autoimmune diseases, or AIFS, a more detailed understanding of their respective roles in the development of inflammation could lead to designing novel therapeutic avenues.https://www.mdpi.com/2073-4409/11/24/4025B cellautoinflammationautoimmunitymevalonate kinase deficiency syndromeKawasaki syndromeinflammatory bone disorders |
| spellingShingle | Moncef Zouali B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes Cells B cell autoinflammation autoimmunity mevalonate kinase deficiency syndrome Kawasaki syndrome inflammatory bone disorders |
| title | B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes |
| title_full | B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes |
| title_fullStr | B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes |
| title_full_unstemmed | B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes |
| title_short | B Cells at the Cross-Roads of Autoimmune Diseases and Auto-Inflammatory Syndromes |
| title_sort | b cells at the cross roads of autoimmune diseases and auto inflammatory syndromes |
| topic | B cell autoinflammation autoimmunity mevalonate kinase deficiency syndrome Kawasaki syndrome inflammatory bone disorders |
| url | https://www.mdpi.com/2073-4409/11/24/4025 |
| work_keys_str_mv | AT moncefzouali bcellsatthecrossroadsofautoimmunediseasesandautoinflammatorysyndromes |