Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis
Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/1042 |
| _version_ | 1797339818229760000 |
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| author | Lluís Rusiñol Lluís Puig |
| author_facet | Lluís Rusiñol Lluís Puig |
| author_sort | Lluís Rusiñol |
| collection | DOAJ |
| description | Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and β-defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others. |
| first_indexed | 2024-03-08T09:52:56Z |
| format | Article |
| id | doaj.art-7a4ec48b739e447b8dc9ab08cf09711e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:52:56Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7a4ec48b739e447b8dc9ab08cf09711e2024-01-29T13:56:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01252104210.3390/ijms25021042Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and PsoriasisLluís Rusiñol0Lluís Puig1Department of Dermatology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, SpainDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, SpainPsoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and β-defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others.https://www.mdpi.com/1422-0067/25/2/1042multi-omicspsoriasisatopic dermatitisimmune mediated inflammatory diseasesgenomicsepigenomics |
| spellingShingle | Lluís Rusiñol Lluís Puig Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis International Journal of Molecular Sciences multi-omics psoriasis atopic dermatitis immune mediated inflammatory diseases genomics epigenomics |
| title | Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis |
| title_full | Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis |
| title_fullStr | Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis |
| title_full_unstemmed | Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis |
| title_short | Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis |
| title_sort | multi omics approach to improved diagnosis and treatment of atopic dermatitis and psoriasis |
| topic | multi-omics psoriasis atopic dermatitis immune mediated inflammatory diseases genomics epigenomics |
| url | https://www.mdpi.com/1422-0067/25/2/1042 |
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