Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits

Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits

Abstract Temporal lobe epilepsy (TLE), one common type of medically refractory epilepsy, is accompanied with altered adult-born dentate granule cells (abDGCs). However, the causal role of abDGCs in recurrent seizures of TLE is not fully understood. Here, taking advantage of optogenetic and chemogene...

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Bibliographic Details
Main Authors: Liying Chen, Yingwei Xu, Heming Cheng, Zhongxia Li, Nanxi Lai, Menghan Li, Yeping Ruan, Yang Zheng, Fan Fei, Cenglin Xu, Jiao Ma, Shuang Wang, Yan Gu, Feng Han, Zhong Chen, Yi Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01433-4

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