Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, Aurangabad
Context: Tuberculosis (TB) patients who do not complete treatment pose a potential public health risk through disease reactivation, increased transmission, and development of drug resistance. Aims: (1) To determine the duration TB patients stay in the treatment before defaulting. (2) Factors associa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Community Medicine |
| Subjects: | |
| Online Access: | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2019;volume=44;issue=1;spage=44;epage=47;aulast=Paunikar |
| _version_ | 1819051031304077312 |
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| author | Apeksha Premnath Paunikar Hrishikesh Arvindrao Khadilkar Mohan Kondiba Doibale Avinash R Lamb |
| author_facet | Apeksha Premnath Paunikar Hrishikesh Arvindrao Khadilkar Mohan Kondiba Doibale Avinash R Lamb |
| author_sort | Apeksha Premnath Paunikar |
| collection | DOAJ |
| description | Context: Tuberculosis (TB) patients who do not complete treatment pose a potential public health risk through disease reactivation, increased transmission, and development of drug resistance. Aims: (1) To determine the duration TB patients stay in the treatment before defaulting. (2) Factors associated with defaulters who had been treated in Government Medical College and Hospital (GMCH), Aurangabad. Setting and Design: The study was conducted at TB Unit of GMCH, Aurangabad, and community. This was a retrospective cohort study. Materials and Methods: Based on record review of 440 bacteriological-confirmed TB patients enrolled in the TB Unit of GMCH, Aurangabad, in 2015 from January 1, to December 31, we collected information on potential risk factors of all confirmed cases by primary and secondary data. For survival analysis, outcome of interest was treatment defaulter. Kaplan–Meier curves, log-rank test, and Cox-proportional hazard regression analysis were used to model outcome of interest. Statistical Analysis Used: Statistical analysis is performed using SPSS version 17. Results: Out of total 440 TB patients registered, 13 patients got defaulted in 2015. Overall mean time of default was 279 days, with 276 days for males against 279 days for females. Many patients interrupted treatment during continuation phase. Treatment defaulters had an association with gender, category at the initiation of treatment, HIV status, smoking, and alcohol consumption. Conclusion: Targeted intervention with the goal toward adherence in persons abusing smoking and alcohol is recommended. Necessary actions need to be initiated in the program to strengthen the follow-up of patients and to bring behavioral changes by proper counseling. |
| first_indexed | 2024-12-21T11:57:28Z |
| format | Article |
| id | doaj.art-7a5046ad709b409eb389b41d967aef42 |
| institution | Directory Open Access Journal |
| issn | 0970-0218 1998-3581 |
| language | English |
| last_indexed | 2024-12-21T11:57:28Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Community Medicine |
| spelling | doaj.art-7a5046ad709b409eb389b41d967aef422022-12-21T19:04:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Community Medicine0970-02181998-35812019-01-01441444710.4103/ijcm.IJCM_292_18Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, AurangabadApeksha Premnath PaunikarHrishikesh Arvindrao KhadilkarMohan Kondiba DoibaleAvinash R LambContext: Tuberculosis (TB) patients who do not complete treatment pose a potential public health risk through disease reactivation, increased transmission, and development of drug resistance. Aims: (1) To determine the duration TB patients stay in the treatment before defaulting. (2) Factors associated with defaulters who had been treated in Government Medical College and Hospital (GMCH), Aurangabad. Setting and Design: The study was conducted at TB Unit of GMCH, Aurangabad, and community. This was a retrospective cohort study. Materials and Methods: Based on record review of 440 bacteriological-confirmed TB patients enrolled in the TB Unit of GMCH, Aurangabad, in 2015 from January 1, to December 31, we collected information on potential risk factors of all confirmed cases by primary and secondary data. For survival analysis, outcome of interest was treatment defaulter. Kaplan–Meier curves, log-rank test, and Cox-proportional hazard regression analysis were used to model outcome of interest. Statistical Analysis Used: Statistical analysis is performed using SPSS version 17. Results: Out of total 440 TB patients registered, 13 patients got defaulted in 2015. Overall mean time of default was 279 days, with 276 days for males against 279 days for females. Many patients interrupted treatment during continuation phase. Treatment defaulters had an association with gender, category at the initiation of treatment, HIV status, smoking, and alcohol consumption. Conclusion: Targeted intervention with the goal toward adherence in persons abusing smoking and alcohol is recommended. Necessary actions need to be initiated in the program to strengthen the follow-up of patients and to bring behavioral changes by proper counseling.http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2019;volume=44;issue=1;spage=44;epage=47;aulast=PaunikarCox proportional hazardlog-ranksurvival analysistreatment defaulters |
| spellingShingle | Apeksha Premnath Paunikar Hrishikesh Arvindrao Khadilkar Mohan Kondiba Doibale Avinash R Lamb Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, Aurangabad Indian Journal of Community Medicine Cox proportional hazard log-rank survival analysis treatment defaulters |
| title | Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, Aurangabad |
| title_full | Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, Aurangabad |
| title_fullStr | Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, Aurangabad |
| title_full_unstemmed | Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, Aurangabad |
| title_short | Survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital, Aurangabad |
| title_sort | survival analysis of treatment defaulters among tuberculosis patients in government medical college and hospital aurangabad |
| topic | Cox proportional hazard log-rank survival analysis treatment defaulters |
| url | http://www.ijcm.org.in/article.asp?issn=0970-0218;year=2019;volume=44;issue=1;spage=44;epage=47;aulast=Paunikar |
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