A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment
Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports h...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-09-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689719859539 |
| _version_ | 1819045491928727552 |
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| author | Konstantinos Pantos Mara Simopoulou Agni Pantou Anna Rapani Petroula Tsioulou Nikolaos Nitsos Stephen Syrkos Athanasios Pappas Michael Koutsilieris Konstantinos Sfakianoudis |
| author_facet | Konstantinos Pantos Mara Simopoulou Agni Pantou Anna Rapani Petroula Tsioulou Nikolaos Nitsos Stephen Syrkos Athanasios Pappas Michael Koutsilieris Konstantinos Sfakianoudis |
| author_sort | Konstantinos Pantos |
| collection | DOAJ |
| description | Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports have shown promising results with the use of PRP in ovarian treatment, regarding ovarian regeneration and reactivation of folliculogenesis. This case series reports on two women with premature ovarian failure (POF) aged 40 and 27 years, respectively, and one menopausal woman aged 46 years. All patients presented with lack of menstrual cycle for over a year. The women reported previous failed in vitro fertilization (IVF) attempts, and, after rejecting the option of oocyte donation, they opted for the approach of autologous ovarian PRP treatment. Following PRP treatment, the three patients were invited to conceive naturally. The primary outcome was the restoration of menstruation following autologous ovarian PRP treatment, as well as an improvement in hormonal profile, a decrease in follicle-stimulating hormone (FSH) levels, and a concurrent increase in anti-Müllerian hormone (AMH) levels. Further to that, our patients achieved pregnancy through natural conception within 2–6 months following PRP treatment, resulting in currently ongoing complication-free clinical pregnancies – a first report in the literature for menopausal and POF patients. Implementation of PRP should be further investigated through randomized controlled trials (RCTs), as it may hold the key to successful treatment for a certain cohort of patients exploring reproductive treatment options following menopause. |
| first_indexed | 2024-12-21T10:29:26Z |
| format | Article |
| id | doaj.art-7a505b16d61b47908e5361108ac911a7 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-21T10:29:26Z |
| publishDate | 2019-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-7a505b16d61b47908e5361108ac911a72022-12-21T19:07:14ZengSAGE PublishingCell Transplantation0963-68971555-38922019-09-012810.1177/0963689719859539A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma TreatmentKonstantinos Pantos0Mara Simopoulou1Agni Pantou2Anna Rapani3Petroula Tsioulou4Nikolaos Nitsos5Stephen Syrkos6Athanasios Pappas7Michael Koutsilieris8Konstantinos Sfakianoudis9 Centre for Human Reproduction, Genesis Athens Clinic, Greece Department of Physiology, Medical School, National and Kapodistrian University of Athens, Greece Centre for Human Reproduction, Genesis Athens Clinic, Greece Department of Physiology, Medical School, National and Kapodistrian University of Athens, Greece Department of Physiology, Medical School, National and Kapodistrian University of Athens, Greece Microbiology-Biochemical Department, Genesis Athens Clinic, Greece Centre for Human Reproduction, Genesis Athens Clinic, Greece Centre for Human Reproduction, Genesis Athens Clinic, Greece Department of Physiology, Medical School, National and Kapodistrian University of Athens, Greece Centre for Human Reproduction, Genesis Athens Clinic, GreeceSince the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports have shown promising results with the use of PRP in ovarian treatment, regarding ovarian regeneration and reactivation of folliculogenesis. This case series reports on two women with premature ovarian failure (POF) aged 40 and 27 years, respectively, and one menopausal woman aged 46 years. All patients presented with lack of menstrual cycle for over a year. The women reported previous failed in vitro fertilization (IVF) attempts, and, after rejecting the option of oocyte donation, they opted for the approach of autologous ovarian PRP treatment. Following PRP treatment, the three patients were invited to conceive naturally. The primary outcome was the restoration of menstruation following autologous ovarian PRP treatment, as well as an improvement in hormonal profile, a decrease in follicle-stimulating hormone (FSH) levels, and a concurrent increase in anti-Müllerian hormone (AMH) levels. Further to that, our patients achieved pregnancy through natural conception within 2–6 months following PRP treatment, resulting in currently ongoing complication-free clinical pregnancies – a first report in the literature for menopausal and POF patients. Implementation of PRP should be further investigated through randomized controlled trials (RCTs), as it may hold the key to successful treatment for a certain cohort of patients exploring reproductive treatment options following menopause.https://doi.org/10.1177/0963689719859539 |
| spellingShingle | Konstantinos Pantos Mara Simopoulou Agni Pantou Anna Rapani Petroula Tsioulou Nikolaos Nitsos Stephen Syrkos Athanasios Pappas Michael Koutsilieris Konstantinos Sfakianoudis A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment Cell Transplantation |
| title | A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment |
| title_full | A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment |
| title_fullStr | A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment |
| title_full_unstemmed | A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment |
| title_short | A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment |
| title_sort | case series on natural conceptions resulting in ongoing pregnancies in menopausal and prematurely menopausal women following platelet rich plasma treatment |
| url | https://doi.org/10.1177/0963689719859539 |
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